Volume : 50 µg
Clone Number :
Aliases : KIAA0616 antibody; CREB reg µLated transcription coactivator 1 antibody; CREB-reg µLated transcription coactivator 1 antibody; CRTC1 antibody; CRTC1_HUMAN antibody; FLJ14027 antibody; MECT 1 antibody; Mucoepidermoid carcinoma translocated 1 antibody; Mucoepidermoid carcinoma translocated protein 1 antibody; TORC-1 antibody; TORC1 antibody; Transducer of CREB protein 1 antibody; Transducer of reg µLated cAMP response element binding protein 1 antibody; Transducer of reg µLated cAMP response element-binding protein (CREB) 1 antibody; Transducer of reg µLated cAMP response element-binding protein 1 antibody; WAMTP1 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q6UUV9
Immunogen : Recombinant Human CREB-reg µLated transcription coactivator 1 protein (1-248AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Transcriptional coactivator for CREB1 which activates transcription thro µgh both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 \'Ser-133\' phosphorylation. Enhances the interaction of CREB1 with TAF4. Reg µLates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity). In concert with SIK1 reg µLates the light-induced entrainment of the circadian clock. In response to light stim µLus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : CRTC1
Research Areas : Epigenetics and Nuclear Signaling; Metabolism; Signal transduction