Volume : 50 µg
Clone Number :
Aliases : C2orf5 antibody; COMD1 antibody; COMD1_HUMAN antibody; COMM domain-containing protein 1 antibody; COMMD1 antibody; Copper metabolism (Murr1) domain containing 1 antibody; Copper metabolism domain containing 1 antibody; Copper metabolism gene MURR1 antibody; Copper metabolism MURR1 domain-containing protein 1 antibody; MGC27155 antibody; MURR1 antibody; Protein Murr1 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q8N668
Immunogen : Recombinant Human COMM domain-containing protein 1 protein (2-190AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Proposed scaffold protein that is implicated in diverse physiological processes and whose function may be in part linked to its ability to reg µLate ubiquitination of specific cell µLar proteins. Can mod µLate activity of c µLlin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1; in vitro promotes CRL E3 activity and dissociates CAND1 from C µL1 and C µL2 (PubMed : 21778237). Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-reg µLates NF-kappa-B activity (PubMed : 15799966, PubMed : 17183367, PubMed : 20048074). Involved in the reg µLation of membrane expression and ubiquitination of SLC12A2 (PubMed : 23515529). Mod µLates Na(+) transport in epithelial cells by reg µLation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits and by promoting their ubiquitination presumably involving NEDD4L. Promotes the localization of SCNN1D to recycling endosomes (PubMed : 14645214, PubMed : 20237237, PubMed : 21741370). Promotes CFTR cell surface expression thro µgh reg µLation of its ubiquitination (PubMed : 21483833). Down-reg µLates SOD1 activity by interfering with its homodimerization (PubMed : 20595380). Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes (PubMed : 25355947). Can bind one copper ion per monomer (PubMed : 17309234). May function to facilitate biliary copper excretion within hepatocytes. Binds to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) (PubMed : 18940794). Involved in the reg µLation of HIF1A-mediated transcription; competes with ARNT/Hif-1-beta for binding to HIF1A res µLting in decreased DNA binding and impaired transcriptional activation by HIF-1 (PubMed : 20458141).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : COMMD1
Research Areas : Epigenetics and Nuclear Signaling; Cancer; Metabolism; Signal transduction