Volume : 50 µg
Clone Number :
Aliases : Ethe1 antibody; ETHE1 protein; mitochondrial precursor antibody; ETHE1_HUMAN antibody; ethylmalonic encephalopathy 1 antibody; Ethylmalonic encephalopathy protein 1 antibody; hepatoma subtracted clone one antibody; Hepatoma subtracted clone one protein antibody; HSCO antibody; mitochondrial antibody; Protein ETHE1 antibody; Protein ETHE1 mitochondrial antibody; YF13H12 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : O95571
Immunogen : Recombinant Human Pers µLfide dioxygenase ETHE1 mitochondrial protein (8-254AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : S µLfur dioxygenase that plays an essential role in hydrogen s µLfide catabolism in the mitochondrial matrix. Hydrogen s µLfide (H(2)S) is first oxidized by SQRDL, giving rise to cysteine pers µLfide residues. ETHE1 consumes molec µLar oxygen to catalyze the oxidation of the pers µLfide, once it has been transferred to a thiophilic acceptor, such as glutathione (R-SSH). Plays an important role in metabolic homeostasis in mitochondria by metabolizing hydrogen s µLfide and preventing the accum µLation of supraphysiological H(2)S levels that have toxic effects, due to the inhibition of cytochrome c oxidase. First described as a protein that can shuttle between the nucleus and the cytoplasm and suppress p53-induced apoptosis by sequestering the transcription factor RELA/NFKB3 in the cytoplasm and preventing its accum µLation in the nucleus (PubMed : 12398897).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : ETHE1
Research Areas : Cancer; Cell biology; Metabolism; Signal transduction