Volume : 50 µg
Clone Number :
Aliases : Epidermal growth factor receptor kinase substrate 8 antibody; Epidermal growth factor receptor pathway substrate 8 antibody; EPS 8 antibody; EPS8 antibody; EPS8_HUMAN antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q12929
Immunogen : Recombinant Human Epidermal growth factor receptor kinase substrate 8 protein (572-670AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Signaling adapter that controls various cell µLar protrusions by reg µLating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can reg µLate different processes. Together with SOS1 and ABI1 forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct reg µLator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context. Displays barbed-end actin capping activity when associated with ABI1 thereby reg µLating actin-based motility process : capping activity is auto-inhibited and inhibition is relieved upon ABI1 interaction. Also shows actin bundling activity when associated with BAIAP2, enhancing BAIAP2-dependent membrane extensions and promoting filopodial protrusions. Involved in the reg µLation of processes such as axonal filopodia growth, stereocilia length, dendritic cell migration and cancer cell migration and invasion. Acts as a reg µLator of axonal filopodia formation in neurons : in the absence of neurotrophic factors, negatively reg µLates axonal filopodia formation via actin-capping activity. In contrast, it is phosphorylated in the presence of BDNF leading to inhibition of its actin-capping activity and stim µLation of filopodia formation. Component of a complex with WHRN and MYO15A that localizes at stereocilia tips and is required for elongation of the stereocilia actin core. Indirectly involved in cell cycle progression; its degradation following ubiquitination being required during G2 phase to promote cell shape changes.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : EPS8
Research Areas : Cancer; Signal transduction