Volume : 50 µg
Clone Number :
Aliases : forkhead box A1 antibody; Forkhead box protein A1 antibody; FOX A1 antibody; FOXA1 antibody; FOXA1_HUMAN antibody; hepatocyte nuclear factor 3 alpha antibody; Hepatocyte nuclear factor 3-alpha antibody; HNF 3A antibody; HNF-3-alpha antibody; HNF-3A antibody; HNF3A antibody; MGC33105 antibody; TCF 3A antibody; TCF-3A antibody; TCF3A antibody; Transcription factor 3A antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P55317
Immunogen : Recombinant Human Hepatocyte nuclear factor 3-alpha protein (367-472AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and reg µLation of gene expression in differentiated tissues. Is tho µght to act as a \'pioneer\' factor opening the compacted chromatin for other proteins thro µgh interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5\'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3\' (By similarity). Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at \'Lys-5\' (H3K4me2) in estrogen-reg µLated genes. Involved in the development of m µLtiple endoderm-derived organ systems such as liver, pancreas, lung and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles (By similarity). Mod µLates the transcriptional activity of nuclear hormone receptors. Is involved in ESR1-mediated transcription; required for ESR1 binding to the NKX2-1 promoter in breast cancer cells; binds to the RPRM promoter and is required for the estrogen-induced repression of RPRM. Involved in reg µLation of apoptosis by inhibiting the expression of BCL2. Involved in cell cycle reg µLation by activating expression of CDKN1B, alone or in conjunction with BRCA1. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting reg µLatory regions of these genes. Involved in glucose homeostasis.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : FOXA1
Research Areas : Epigenetics and Nuclear Signaling