Volume : 50 µg
Clone Number :
Aliases : Down reg µLated in renal cell carcinoma 1 antibody; Down-reg µLated in renal cell carcinoma 1 antibody; Downreg µLated in renal cell carcinoma antibody; DRR1 antibody; F107A_HUMAN antibody; FAM107A antibody; Family with sequence similarity 107; member A antibody; FLJ30158 antibody; FLJ45473 antibody; Protein FAM107A antibody; Protein TU3A antibody; TU3A antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : O95990
Immunogen : Recombinant Human Actin-associated protein FAM107A protein (1-144AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Stress-inducible actin-binding protein that plays a role in synaptic and cognitive functions by mod µLating actin filamentous (F-actin) dynamics. Mediates polymerization of glob µLar actin to F-actin. Also binds to, stabilizes and bundles F-actin. Involved in synaptic function by reg µLating neurite outgrowth in an actin-dependent manner and for the acquisition of hippocampus-dependent cognitive function, such as learning and long-term memory (By similarity). Plays a role in the actin and microtub µLe cytoskeleton organization; negatively reg µLates focal adhesion (FA) assembly promoting malignant glial cell migration in an actin-, microtub µLe- and MAP1A-dependent manner (PubMed : 20543869). Also involved in neuroblastoma G1/S phase cell cycle progression and cell proliferation inhibition by stim µLating ubiquitination of NF-kappa-B subunit RELA and NF-kappa-B degradation in a COMMD1- and actin-dependent manner (PubMed : 10564580, PubMed : 28604741). May play a role in tumor development (PubMed : 10564580).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : FAM107A
Research Areas : Cancer; Cell biology