Volume : 50 µg
Clone Number :
Aliases : 5 HT 2 antibody; 5 HT 2A antibody; 5 HT2 receptor antibody; 5 HT2A antibody; 5 hydroxytryptamine receptor 2A antibody; 5-HT-2 antibody; 5-HT-2A antibody; 5-hydroxytryptamine (serotonin) receptor 2A; G protein-coupled antibody; 5-hydroxytryptamine 2A receptor antibody; 5-hydroxytryptamine receptor 2A antibody; 5HT2A_HUMAN antibody; HTR 2 antibody; HTR 2A antibody; HTR2 antibody; HTR2; formerly antibody; HTR2A antibody; serotonin 5-HT-2 receptor; formerly antibody; serotonin 5-HT-2A receptor antibody; Serotonin receptor 2A antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P28223
Immunogen : Recombinant Human 5-hydroxytryptamine receptor 2A protein (385-471AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various dr µgs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and mod µLates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that mod µLates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca2+ ions from intracell µLar stores. Affects neural activity, perception, cognition and mood. Plays a role in the reg µLation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : HTR2A
Research Areas : Neuroscience; Metabolism