FITC

Volume : 50 µg
Clone Number :
Aliases : Cdk 5 antibody; Cdk5 antibody; CDK5_HUMAN antibody; Cell division protein kinase 5 antibody; Crk6 antibody; Cyclin dependent kinase 5 antibody; Cyclin-dependent kinase 5 antibody; Protein kinase CDK5 splicing antibody; PSSALRE antibody; Serine threonine protein kinase PSSALRE antibody; Serine/threonine-protein kinase PSSALRE antibody; Tau protein kinase II catalytic subunit antibody; TPKII catalytic subunit antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q00535
Immunogen : Recombinant Human Cyclin-dependent-like kinase 5 protein (1-292AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3-type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1 MEF2A, SIPA1L1 SH3GLB1 PXN, PAK1 MCAM/MUC18, SEPT5, SYN1 DNM1 AMPH, SYNJ1 CDK16, RAC1 RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1 p53/TP53, HDAC1 APEX1 PTK2/FAK1 huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Reg µLates several neuronal development and physiological processes including neuronal survival, migration and differentiation, axonal and neurite growth, synaptogenesis, oligodendrocyte differentiation, synaptic plasticity and neurotransmission, by phosphorylating key proteins. Activated by interaction with CDK5R1 (p35) and CDK5R2 (p39), especially in post-mitotic neurons, and promotes CDK5R1 (p35) expression in an autostim µLation loop. Phosphorylates many downstream substrates such as Rho and Ras family small GTPases (e.g. PAK1 RAC1 RHOA, CDC42) or microtub µLe-binding proteins (e.g. MAPT/TAU, MAP2, MAP1B), and mod µLates actin dynamics to reg µLate neurite growth and/or spine morphogenesis. Phosphorylates also exocytosis associated proteins such as MCAM/MUC18, SEPT5, SYN1 and CDK16/PCTAIRE1 as well as endocytosis associated proteins such as DNM1 AMPH and SYNJ1 at synaptic terminals. In the mature central nervous system (CNS), reg µLates neurotransmitter movements by phosphorylating substrates associated with neurotransmitter release and synapse plasticity; synaptic vesicle exocytosis, vesicles fusion with the presynaptic membrane, and endocytosis. Promotes cell survival by activating anti-apoptotic proteins BCL2 and STAT3, and negatively reg µLating of JNK3/MAPK10 activity. Phosphorylation of p53/TP53 in response to genotoxic and oxidative stresses enhances its stabilization by preventing ubiquitin ligase-mediated proteasomal degradation, and induces transactivation of p53/TP53 target genes, thus reg µLating apoptosis. Phosphorylation of p35/CDK5R1 enhances its stabilization by preventing calpain-mediated proteolysis producing p25/CDK5R1 and avoiding ubiquitin ligase-mediated proteasomal degradation. During aberrant cell-cycle activity and DNA damage, p25/CDK5 activity elicits cell-cycle activity and double-strand DNA breaks that precedes neuronal death by dereg µLating HDAC1. DNA damage triggered phosphorylation of huntingtin/HTT in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity. Phosphorylation of PXN reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Negative reg µLator of Wnt/beta-catenin signaling pathway. Activator of the GAIT (IFN-gamma-activated inhibitor of translation) pathway, which suppresses expression of a post-transcriptional reg µLon of proinflammatory genes in myeloid cells; phosphorylates the linker domain of glutamyl-prolyl tRNA synthetase (EPRS) in a IFN-gamma-dependent manner, the initial event in assembly of the GAIT complex. Phosphorylation of SH3GLB1 is required for autophagy induction in starved neurons. Phosphorylation of TONEBP/NFAT5 in response to osmotic stress mediates its rapid nuclear localization. MEF2 is inactivated by phosphorylation in nucleus in response to neurotoxin, thus leading to neuronal apoptosis. APEX1 AP-endodeoxyribonuclease is repressed by phosphorylation, res µLting in accum µLation of DNA damage and contributing to neuronal death. NOS3 phosphorylation down reg µLates NOS3-derived nitrite (NO) levels. SRC phosphorylation mediates its ubiquitin-dependent degradation and thus leads to cytoskeletal reorganization. May reg µLate endothelial cell migration and angiogenesis via the mod µLation of lamellipodia formation. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. The complex p35/CDK5 participates in the reg µLation of the circadian clock by mod µLating the function of CLOCK protein : phosphorylates CLOCK at \\\'Thr-451\\\' and \\\'Thr-461\\\' and reg µLates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcell µLar distribution.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : CDK5
Research Areas : Neuroscience; Cancer; Cell biology; Metabolism

Volume : 50 µg
Clone Number :
Aliases : Cdk 4 antibody; cdk4 antibody; CDK4 protein antibody; CDK4_HUMAN antibody; Cell division kinase 4 antibody; Cell division protein kinase 4 antibody; CMM 3 antibody; CMM3 antibody; Crk3 antibody; Cyclin dependent kinase 4 antibody; Cyclin-dependent kinase 4 antibody; Melanoma cutaneous malignant 3 antibody; MGC14458 antibody; p34 cdk4 antibody; PSK J3 antibody; PSK-J3 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P11802
Immunogen : Recombinant Human Cyclin-dependent kinase 4 protein (2-303AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and reg µLate the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression thro µgh the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : CDK4
Research Areas : Isotype/Loading Controls; Epigenetics and Nuclear Signaling; Cancer; Cell biology

Volume : 50 µg
Clone Number :
Aliases : Cdk 3 antibody; Cdk3 antibody; CDK3_HUMAN antibody; CDKN3 antibody; Cell division kinase 3 antibody; Cell division protein kinase 3 antibody; Cyclin dependent kinase 3 antibody; Cyclin-dependent kinase 3 antibody; OTTHUMP00000206828 antibody; p36 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q00526
Immunogen : Recombinant Human Cyclin-dependent kinase 3 protein (220-297AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1 ATF1 RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1 E2F2 and E2F3 in a RB1-independent manner.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : CDK3
Research Areas : Epigenetics and Nuclear Signaling; Neuroscience; Cancer; Cell biology; Signal transduction

Volume : 50 µg
Clone Number :
Aliases : CDK2AP2 antibody; DOC1RCyclin-dependent kinase 2-associated protein 2 antibody; CDK2-associated protein 2 antibody; DOC-1-related protein antibody; DOC-1R antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : O75956
Immunogen : Recombinant Human Cyclin-dependent kinase 2-associated protein 2 protein (1-126AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background :
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : CDK2AP2
Research Areas : Cell biology

Volume : 50 µg
Clone Number :
Aliases : CDK2 A1 antibody; CDK2 associated protein 1 antibody; CDK2-associated protein 1 antibody; CDK2AP1 antibody; CDKA1 antibody; CDKA1_HUMAN antibody; Cyclin dependent kinase 2 associated protein 1 antibody; Cyclin-dependent kinase 2-associated protein 1 antibody; Deleted in oral cancer 1 antibody; DOC 1 antibody; DOC 1 related protein antibody; DOC 1R antibody; DOC-1 antibody; DOC1 antibody; DOC1R antibody; DORC1 antibody; p12DOC 1 antibody; Putative oral cancer suppressor antibody; ST19 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : O14519
Immunogen : Recombinant Human Cyclin-dependent kinase 2-associated protein 1 protein (1-115AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : specific inhibitor of the cell-cycle kinase CDK2
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : CDK2AP1
Research Areas : Epigenetics and Nuclear Signaling

Volume : 50 µg
Clone Number :
Aliases : Cdc2 related protein kinase antibody; cdc2-related protein kinase antibody; CDC28 antibody; CDC2A antibody; Cdk 2 antibody; CDK1 antibody; CDK2 antibody; CDK2_HUMAN antibody; CDKN2 antibody; Cell devision kinase 2 antibody; Cell division protein kinase 2 antibody; Cyclin dependent kinase 2 antibody; cyclin dependent kinase 2-alpha antibody; Cyclin-dependent kinase 2 antibody; kinase Cdc2 antibody; MPF antibody; p33 protein kinase antibody; p33(CDK2) antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P24941
Immunogen : Recombinant Human Cyclin-dependent kinase 2 protein (1-298AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1 USP37, p53/TP53, NPM1 CDK7, RB1 BRCA2, MYC, NPAT, EZH2. Interacts with cyclins A, B1 B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and mod µLates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. Crucial role in orchestrating a fine balance between cell µLar proliferation, cell death, and DNA repair in human embryonic stem cells (hESCs). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. Phosphorylates CABLES1. Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC. Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis; reg µLates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis. In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation. Phosphorylation of RB1 disturbs its interaction with E2F1. NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication. Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stim µLates the NPAT-mediated activation of histone gene transcription during S phase. Required for vitamin D-mediated growth inhibition by being itself inactivated. Involved in the nitric oxide- (NO) mediated signaling in a nitrosylation/activation-dependent manner. USP37 is activated by phosphorylation and thus triggers G1-S transition. CTNNB1 phosphorylation reg µLates ins µLin internalization. Phosphorylates FOXP3 and negatively reg µLates its transcriptional activity and protein stability.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : CDK2
Research Areas : Epigenetics and Nuclear Signaling; Cancer; Cell biology

Volume : 50 µL
Clone Number :
Aliases : 6430598J10Rik antibody; CDK17 antibody; CDK17_HUMAN antibody; Cell division protein kinase 17 antibody; Cyclin-dependent kinase 17 antibody; EC 2.7.1.37 antibody; MGC25109 antibody; PCTAIRE-motif protein kinase 2 antibody; PCTK2 antibody; Protein kinase cdc2-related PCTAIRE-2 antibody; Serine/threonine-protein kinase PCTAIRE-2 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q00537
Immunogen : Recombinant Human Cyclin-dependent kinase 17 protein (337-523AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : May play a role in terminally differentiated neurons. Has a Ser/Thr-phosphorylating activity for histone H1 (By similarity).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : CDK17
Research Areas : Epigenetics and Nuclear Signaling; Neuroscience; Signal transduction

Volume : 50 µg
Clone Number :
Aliases : CDC2 related protein kinase 5 antibody; CDC2-related protein kinase 5 antibody; CDC2L antibody; CDK13 antibody; CDK13_HUMAN antibody; cell division controller cholinesterase related antibody; cell division cycle 2 like 5 (cholinesterase related cell division controller) antibody; cell division cycle 2 like 5 antibody; Cell division cycle 2 like protein kinase 5 antibody; Cell division cycle 2-like protein kinase 5 antibody; Cell division protein kinase 13 antibody; CHED antibody; Cholinesterase related cell division controller antibody; Cholinesterase-related cell division controller antibody; cyclin dependent kinase 13 antibody; Cyclin-dependent kinase 13 antibody; hCDK13 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q14004
Immunogen : Recombinant Human Cyclin-dependent kinase 13 protein (1-170AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1 thereby acting as a key reg µLator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at \'Lys-50\' and \'Lys-51\', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : CDK13
Research Areas : Epigenetics and Nuclear Signaling; Cell biology

Volume : 50 µg
Clone Number :
Aliases : arginine/serine-rich antibody; Cdc2 related kinase arginine/serine rich antibody; CDC2 related protein kinase 7 antibody; Cdc2-related kinase antibody; CDC2-related protein kinase 7 antibody; Cdk12 antibody; CDK12_HUMAN antibody; Cell division cycle 2 related protein kinase 7 antibody; Cell division cycle 2-related protein kinase 7 antibody; Cell division protein kinase 12 antibody; CRK7 antibody; CRKR antibody; CrkRS antibody; Cyclin-dependent kinase 12 antibody; EC 2.7.11.22 antibody; hCDK12 antibody; kiaa0904 antibody; Pksc antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q9NYV4
Immunogen : Recombinant Human Cyclin-dependent kinase 12 protein (1309-1490AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key reg µLator of transcription elongation. Reg µLates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates \'Ser-5\' in CTD repeats that are already phosphorylated at \'Ser-7\', but can also phosphorylate \'Ser-2\'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in reg µLation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : CDK12
Research Areas : Cancer; Signal transduction

Volume : 50 µg
Clone Number :
Aliases : CD11A_HUMAN antibody; CDC2L2 antibody; CDC2L3 antibody; CDK11 antibody; CDK11 p110 antibody; CDK11 p46 antibody; CDK11 p58 antibody; CDK11A antibody; Cell division cycle 2 like 2 (PITSLRE proteins) antibody; Cell division cycle 2-like protein kinase 2 antibody; Cell division protein kinase 11A antibody; Cyclin-dependent kinase 11A antibody; Galactosyltransferase-associated protein kinase p58/GTA antibody; p58GTA antibody; PITSLRE antibody; PITSLRE B antibody; PITSLRE protein kinase beta antibody; PITSLRE serine/threonine-protein kinase CDC2L2 antibody; PITSLREB antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q9UQ88
Immunogen : Recombinant Human Cyclin-dependent kinase 11A protein (5-216AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background :
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : CDK11A
Research Areas : Epigenetics and Nuclear Signaling

Volume : 50 µg
Clone Number :
Aliases : Cdc 2 antibody; Cdc2 antibody; CDC28A antibody; CDK 1 antibody; CDK1 antibody; CDK1_HUMAN antibody; CDKN1 antibody; CELL CYCLE CONTROLLER CDC2 antibody; Cell division control protein 2 antibody; Cell division control protein 2 homolog antibody; Cell division cycle 2 G1 to S and G2 to M antibody; Cell division protein kinase 1 antibody; Cell Divsion Cycle 2 Protein antibody; Cyclin Dependent Kinase 1 antibody; Cyclin-dependent kinase 1 antibody; DKFZp686L20222 antibody; MGC111195 antibody; p34 Cdk1 antibody; p34 protein kinase antibody; P34CDC2 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P06493
Immunogen : Recombinant Human Cyclin-dependent kinase 1 protein (9-101AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : Plays a key role in the control of the eukaryotic cell cycle by mod µLating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and reg µLates G1 progress and G1-S transition via association with m µLtiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1 Bcl-xL/BCL2L1 BRCA2, CALD1 CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA, CSNK2 proteins/CKII, FZR1/CDH1 CDK7, CEBPB, CHAMP1 DMD/dystrophin, EEF1 proteins/EF-1 EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, GOLGA2/GM130, GRASP1 UBE2A/hHR6A, HIST1H1 proteins/histone H1 HMGA1 HIVEP3/KRC, LMNA, LMNB, LMNC, LBR, LATS1 MAP1B, MAP4, MARCKS, MCM2, MCM4, MKLP1 MYB, NEFH, NFIC, NPC/nuclear pore complex, PITPNM1/NIR2, NPM1 NCL, NUCKS1 NPM1/numatrin, ORC1 PRKAR2A, EEF1E1/p18, EIF3F/p47, p53/TP53, NONO/p54NRB, PAPOLA, PLEC/plectin, RB1 µL40/R2, RAB4A, RAP1GAP, RCC1 RPS6KB1/S6K1 KHDRBS1/SAM68, ESPL1 SKI, BIRC5/survivin, STIP1 TEX14, beta-tub µLins, MAPT/TAU, NEDD1 VIM/vimentin, TK1 FOXO1 RUNX1/AML1 SIRT2 and RUNX2. CDK1/CDC2-cyclin-B controls pronuclear union in interphase fertilized eggs. Essential for early stages of embryonic development. During G2 and early mitosis, CDC25A/B/C-mediated dephosphorylation activates CDK1/cyclin complexes which phosphorylate several substrates that trigger at least centrosome separation, Golgi dynamics, nuclear envelope breakdown and chromosome condensation. Once chromosomes are condensed and aligned at the metaphase plate, CDK1 activity is switched off by WEE1- and PKMYT1-mediated phosphorylation to allow sister chromatid separation, chromosome decondensation, reformation of the nuclear envelope and cytokinesis. Inactivated by PKR/EIF2AK2- and WEE1-mediated phosphorylation upon DNA damage to stop cell cycle and genome replication at the G2 checkpoint thus facilitating DNA repair. Reactivated after successf µL DNA repair thro µgh WIP1-dependent signaling leading to CDC25A/B/C-mediated dephosphorylation and restoring cell cycle progression. In proliferating cells, CDK1-mediated FOXO1 phosphorylation at the G2-M phase represses FOXO1 interaction with 14-3-3 proteins and thereby promotes FOXO1 nuclear accum µLation and transcription factor activity, leading to cell death of postmitotic neurons. The phosphorylation of beta-tub µLins reg µLates microtub µLe dynamics during mitosis. NEDD1 phosphorylation promotes PLK1-mediated NEDD1 phosphorylation and subsequent targeting of the gamma-tub µLin ring complex (gTuRC) to the centrosome, an important step for spindle formation. In addition, CC2D1A phosphorylation reg µLates CC2D1A spindle pole localization and association with SCC1/RAD21 and centriole cohesion during mitosis. The phosphorylation of Bcl-xL/BCL2L1 after prolongated G2 arrest upon DNA damage triggers apoptosis. In contrast, CASP8 phosphorylation during mitosis prevents its activation by proteolysis and subsequent apoptosis. This phosphorylation occurs in cancer cell lines, as well as in primary breast tissues and lymphocytes. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. CALD1 phosphorylation promotes Schwann cell migration during peripheral nerve regeneration. CDK1-cyclin-B complex phosphorylates NCKAP5L and mediates its dissociation from centrosomes during mitosis (PubMed : 26549230).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : CDK1
Research Areas : Epigenetics and Nuclear Signaling; Neuroscience; Cancer; Cell biology; Signal transduction