Volume : 50 µL
Clone Number :
Aliases : 12-O-tetradecanoylphorbol 13-acetate repressed protein 1 antibody; AI174028 antibody; C-X-C motif chemokine 12 antibody; Chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) antibody; Chemokine (C-X-C motif) ligand 12 antibody; Chemokine CXC motif ligand 12 antibody; cxcl12 antibody; hIRH antibody; hSDF-1 antibody; Intercrine reduced in hepatomas antibody; IRH antibody; OTTHUMP00000019491 antibody; PBSF antibody; Pre-B cell growth-stim µLating factor antibody; SCYB12 antibody; SDF 1 antibody; SDF-1 antibody; SDF-1-alpha(3-67) antibody; SDF-1a antibody; SDF-1b antibody; SDF1_HUMAN antibody; SDF1A antibody; SDF1B antibody; Stromal cell-derived factor 1 antibody; Stromal cell-derived factor 1 delta antibody; Stromal cell-derived factor 1 gamma antibody; Stromal cell-derived factor 1a antibody; Stromal cell-derived factor-1 alpha antibody; Thymic lymphoma cell-stim µLating factor antibody; Tlsf antibody; TLSF-a antibody; TLSF-b antibody; Tlsfa antibody; Tlsfb antibody; TPAR1 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P48061
Immunogen : Recombinant Human Stromal cell-derived factor 1 protein (22-89AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracell µLar calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Acts as a positive reg µLator of monocyte migration and a negative reg µLator of monocyte adhesion via the LYN kinase. Stim µLates migration of monocytes and T-lymphocytes thro µgh its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1 a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 thro µgh LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-reg µLation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventric µLar septum formation.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Antigen Affinity purified & Affinity purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : CXCL12
Research Areas : Others
