Volume : 50 µg
Clone Number :
Aliases : AA407514 antibody; EC 2.7.10.2 antibody; FLJ26625 antibody; Hck 2 antibody; JTK 8 antibody; JTK8 antibody; Lck/Yes related novel protein tyrosine kinase antibody; LYN antibody; LYN proto oncogene, Src family tyrosine kinase antibody; LYN_HUMAN antibody; ONCOGENE LYN antibody; p53Lyn antibody; p56Lyn antibody; Tyrosine protein kinase LYN antibody; Tyrosine-protein kinase Lyn antibody; V yes 1 Yamaguchi sarcoma viral related oncogene homolog antibody; Yamaguchi sarcoma viral (v yes 1) related oncogene homolog antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P07948
Immunogen : Recombinant Human Tyrosine-protein kinase Lyn protein (135-282AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the reg µLation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative reg µLator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-reg µLation and termination. Plays an important role in the reg µLation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1 FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils. Acts downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well as the receptors for IL3, IL5 and CSF2. Plays an important role in integrin signaling. Reg µLates cell proliferation, survival, differentiation, migration, adhesion, degran µLation, and cytokine release. Down-reg µLates signaling pathways by phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for phosphatases, such as PTPN6/SHP-1 PTPN11/SHP-2 and INPP5D/SHIP-1 that mod µLate signaling by dephosphorylation of kinases and their substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19, CD72, CD79A, CD79B, CSF2RB, DOK1 HCLS1 LILRB3/PIR-B, MS4A2/FCER1B, PTK2B/PYK2, SYK and TEC. Promotes phosphorylation of SIRPA, PTPN6/SHP-1 PTPN11/SHP-2 and INPP5D/SHIP-1. Mediates phosphorylation of the BCR-ABL fusion protein. Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as an effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid differentiation during the switch between proliferation and maturation. Depending on the context, activates or inhibits several signaling cascades. Reg µLates phosphatidylinositol 3-kinase activity and AKT1 activation. Reg µLates activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1 MAPK1/ERK2, MAPK3/ERK1 MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B. Phosphorylates LPXN on \'Tyr-72\'. Kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : LYN
Research Areas : Signal transduction
