FITC

Volume : 50 µg
Clone Number :
Aliases : APC binding protein EB1 antibody; APC binding protein EB2 antibody; APC-binding protein EB2 antibody; EB1 antibody; EB2 antibody; End binding protein 2 antibody; End-binding protein 2 antibody; H.sapiens mRNA for novel T cell activation protein antibody; MAPRE2 antibody; MARE2_HUMAN antibody; Microtub µLe associated protein RP/EB family member 2 antibody; Microtub µLe-associated protein RP/EB family member 2 antibody; RP1 antibody; T cell activation protein EB1 family antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q15555
Immunogen : Recombinant Human Microtub µLe-associated protein RP/EB family member 2 protein (159-240AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : May be involved in microtub µLe polymerization, and spindle function by stabilizing microtub µLes and anchoring them at centrosomes. May play a role in cell migration (By similarity).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : MAPRE2
Research Areas : Cell biology; Signal transduction

Volume : 50 µg
Clone Number :
Aliases : 5530600P05Rik antibody; Adenomatous polyposis coli binding protein EB 1 antibody; Adenomatous polyposis coli binding protein EB1 antibody; AI462499 antibody; AI504412 antibody; APC binding protein EB 1 antibody; APC binding protein EB1 antibody; APC-binding protein EB1 antibody; AW260097 antibody; BIM1p antibody; D2Ertd459e antibody; EB 1 antibody; EB1 antibody; End binding protein 1 antibody; End-binding protein 1 antibody; fa01e12 antibody; fc23e11 antibody; fi33c06 antibody; MAPRE 1 antibody; MAPRE1 antibody; Mapre3 antibody; MARE1_HUMAN antibody; MGC117374 antibody; MGC129946 antibody; MGC52508 antibody; Microtub µLe associated protein RP/EB family member 1 antibody; Microtub µLe-associated protein RP/EB family member 1 antibody; wu : fa01e12 antibody; wu : fc23e11 antibody; wu : fi33c06 antibody; zgc : 55428 antibody; zgc : 77807 antibody; zgc : 85755 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q15691
Immunogen : Recombinant Human Microtub µLe-associated protein RP/EB family member 1 protein (2-268AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : Binds to the plus end of microtub µLes and reg µLates the dynamics of the microtub µLe cytoskeleton. Promotes cytoplasmic microtub µLe nucleation and elongation. May be involved in spindle function by stabilizing microtub µLes and anchoring them at centrosomes. May play a role in cell migration.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : MAPRE1
Research Areas : Tags & Cell Markers; Signal transduction

Volume : 50 µg
Clone Number :
Aliases : MAP kinase-activated protein kinase 5 antibody; MAPK-activated protein kinase 5 antibody; MAPK5_HUMAN antibody; MAPKAP kinase 5 antibody; MAPKAPK-5 antibody; MAPKAPK5 antibody; Mitogen activated protein kinase activated protein kinase 5 antibody; p38-reg µLated/activated protein kinase antibody; PRAK antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q8IW41
Immunogen : Recombinant Human MAP kinase-activated protein kinase 5 protein (200-471AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional reg µLation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1 p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional reg µLation of MYC by mediating phosphorylation of FOXO3 : phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional reg µLators of MYC that bind to the 3\'UTR of MYC transcript and prevent MYC translation. Acts as a negative reg µLator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4 : the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events : upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stim µLation, inducing F-actin rearrangement.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : MAPKAPK5
Research Areas : Cancer

Volume : 50 µg
Clone Number :
Aliases : c Jun kinase 2 antibody; C Jun N terminal kinase 2 antibody; c-Jun N-terminal kinase 2 antibody; JNK 55 antibody; JNK-55 antibody; JNK2 alpha antibody; JNK2 antibody; JNK2 beta antibody; JNK2A antibody; JNK2alpha antibody; JNK2B antibody; JNK2BETA antibody; Jun kinase antibody; MAP kinase 9 antibody; MAPK 9 antibody; Mapk9 antibody; Mitogen activated protein kinase 9 antibody; Mitogen-activated protein kinase 9 antibody; MK09_HUMAN antibody; P54a antibody; p54aSAPK antibody; PRKM9 antibody; Protein kinase, mitogen-activated, 9 antibody; SAPK alpha antibody; SAPK antibody; SAPK1a antibody; Stress activated protein kinase 1a antibody; Stress-activated protein kinase JNK2 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P45984
Immunogen : Recombinant Human Mitogen-activated protein kinase 9 protein (1-424AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracell µLar stim µLi such as proinflammatory cytokines or physical stress stim µLate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK9/JNK2. In turn, MAPK9/JNK2 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus reg µLates AP-1 transcriptional activity. In response to oxidative or ribotoxic stresses, inhibits rRNA synthesis by phosphorylating and inactivating the RNA polymerase 1-specific transcription initiation factor RRN3. Promotes stressed cell apoptosis by phosphorylating key reg µLatory factors including TP53 and YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Upon T-cell receptor (TCR) stim µLation, is activated by CARMA1 BCL10, MAP2K7 and MAP3K7/TAK1 to reg µLate JUN protein levels. Plays an important role in the osmotic stress-induced epithelial tight-junctions disruption. When activated, promotes beta-catenin/CTNNB1 degradation and inhibits the canonical Wnt signaling pathway. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the reg µLation of the circadian clock. MAPK9 isoforms display different binding patterns : alpha-1 and alpha-2 preferentially bind to JUN, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and JUND binds only weakly to it.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : MAPK9
Research Areas : Cancer; Cell biology; Immunology; Metabolism; Signal transduction

Volume : 50 µg
Clone Number :
Aliases : C Jun kinase 2 antibody; c Jun N terminal kinase 1 antibody; c Jun N terminal kinase 2 antibody; c Jun N terminal kinase 3 antibody; c-Jun N-terminal kinase 1 antibody; JNK 46 antibody; JNK 55 antibody; JNK antibody; JNK-46 antibody; JNK1 antibody; JNK1+2+3 antibody; JNK1/2/3 antibody; JNK1A2 antibody; JNK2 antibody; JNK21B1/2 antibody; JNK2A antibody; JNK2ALPHA antibody; JNK2B antibody; JNK2BETA antibody; JNK3 alpha protein kinase antibody; JNK3 antibody; JNK3A antibody; Jun kinase antibody; JUN N terminal kinase antibody; MAP kinase 10 antibody; MAP kinase 8 antibody; MAP kinase 9 antibody; MAP kinase p49 3F12 antibody; MAPK 10 antibody; MAPK 8 antibody; MAPK 9 antibody; MAPK10 antibody; mapk8 antibody; MAPK9 antibody; Mitogen activated protein kinase 10 antibody; Mitogen activated protein kinase 8 antibody; Mitogen activated protein kinase 8 isoform JNK1 alpha1 antibody; Mitogen activated protein kinase 8 isoform JNK1 beta2 antibody; Mitogen activated protein kinase 9 antibody; Mitogen-activated protein kinase 8 antibody; MK08_HUMAN antibody; p493F12 antibody; p54a antibody; p54aSAPK antibody; p54bSAPK antibody; PRKM10 antibody; PRKM8 antibody; PRKM9 antibody; SAPK antibody; SAPK(beta) antibody; SAPK1 antibody; SAPK1a antibody; SAPK1b antibody; SAPK1c antibody; Stress activated protein kinase 1 antibody; Stress activated protein kinase 1a antibody; Stress activated protein kinase 1b antibody; Stress activated protein kinase 1c antibody; Stress activated protein kinase beta antibody; Stress activated protein kinase JNK1 antibody; Stress activated protein kinase JNK2 antibody; Stress activated protein kinase JNK3 antibody; Stress-activated protein kinase 1 antibody; Stress-activated protein kinase 1c antibody; Stress-activated protein kinase JNK1 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P45983
Immunogen : Recombinant Human Mitogen-activated protein kinase 8 protein (5-300AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracell µLar stim µLi such as proinflammatory cytokines or physical stress stim µLate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. In turn, MAPK8/JNK1 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus reg µLates AP-1 transcriptional activity. Phosphorylates the replication licensing factor CDT1 inhibiting the interaction between CDT1 and the histone H4 acetylase HBO1 to replication origins. Loss of this interaction abrogates the acetylation required for replication initiation. Promotes stressed cell apoptosis by phosphorylating key reg µLatory factors including p53/TP53 and Yes-associates protein YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Contributes to the survival of erythroid cells by phosphorylating the antagonist of cell death BAD upon EPO stim µLation. Mediates starvation-induced BCL2 phosphorylation, BCL2 dissociation from BECN1 and thus activation of autophagy. Phosphorylates STMN2 and hence reg µLates microtub µLe dynamics, controlling neurite elongation in cortical neurons. In the developing brain, thro µgh its cytoplasmic activity on STMN2, negatively reg µLates the rate of exit from m µLtipolar stage and of radial migration from the ventric µLar zone. Phosphorylates several other substrates including heat shock factor protein 4 (HSF4), the deacetylase SIRT1 ELK1 or the E3 ligase ITCH. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the reg µLation of the circadian clock (PubMed : 22441692).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : MAPK8
Research Areas : Cancer; Immunology; Signal transduction

Volume : 50 µg
Clone Number :
Aliases : ERK-3 antibody; ERK3 antibody; Extracell µLar signal reg µLated kinase 3 antibody; Extracell µLar signal reg µLated kinase p97 antibody; Extracell µLar signal-reg µLated kinase 3 antibody; HsT17250 antibody; MAP kinase 6 antibody; MAP kinase isoform p97 antibody; MAPK 6 antibody; MAPK6 antibody; Mitogen activated protein kinase 6 antibody; Mitogen-activated protein kinase 6 antibody; MK06_HUMAN antibody; p97 MAPK antibody; p97-MAPK antibody; PRKM6 antibody; Protein kinase mitogen activated 5 antibody; Protein kinase mitogen activated 6 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q16659
Immunogen : Recombinant Human Mitogen-activated protein kinase 6 protein (383-712AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : Atypical MAPK protein. Phosphorylates microtub µLe-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events : upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : MAPK6
Research Areas : Signal transduction; Stem cells

Volume : 50 µg
Clone Number :
Aliases : ERK 1 antibody; ERK-1 antibody; ERK1 antibody; ERT 2 antibody; ERT2 antibody; Extracell µLar Signal Reg µLated Kinase 1 antibody; Extracell µLar signal related kinase 1 antibody; Extracell µLar signal-reg µLated kinase 1 antibody; HGNC6877 antibody; HS44KDAP antibody; HUMKER1A antibody; Ins µLin Stim µLated MAP2 Kinase antibody; Ins µLin-stim µLated MAP2 kinase antibody; MAP kinase 1 antibody; MAP kinase 3 antibody; MAP Kinase antibody; MAP kinase isoform p44 antibody; MAPK 1 antibody; MAPK 3 antibody; MAPK antibody; MAPK1 antibody; Mapk3 antibody; MGC20180 antibody; Microtub µLe Associated Protein 2 Kinase antibody; Microtub µLe-associated protein 2 kinase antibody; Mitogen Activated Protein Kinase 3 antibody; Mitogen-activated protein kinase 1 antibody; Mitogen-activated protein kinase 3 antibody; MK03_HUMAN antibody; OTTHUMP00000174538 antibody; OTTHUMP00000174541 antibody; p44 ERK1 antibody; p44 MAPK antibody; p44-ERK1 antibody; p44-MAPK antibody; P44ERK1 antibody; P44MAPK antibody; PRKM 3 antibody; PRKM3 antibody; Protein Kinase Mitogen Activated 3 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P27361
Immunogen : Recombinant Human Mitogen-activated protein kinase 3 protein (11-379AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cell µLar context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation thro µgh the reg µLation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and reg µLation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the reg µLation of transcription upon stim µLation. However, other substrates are found in the cytosol as well as in other cell µLar organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the reg µLation of the endosomal dynamics, including lysosome processing and endosome cycling thro µgh the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1 ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1 MAP2, MAPT, PXN, SORBS3 or STMN1), reg µLators of apoptosis (such as BAD, BTG2, CASP9, DAPK1 IER3, MCL1 or PPARG), reg µLators of translation (such as EIF4EBP1) and a variety of other signaling-related molec µLes (like ARHGEF2, FRS2 or GRB10). Protein kinases (such as RAF1 RPS6KA1/RSK1 RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1 MKNK2/MNK2, RPS6KA5/MSK1 RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1 DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : MAPK3
Research Areas : Neuroscience; Signal transduction; Stem cells

Volume : 50 µg
Clone Number :
Aliases : CSAID Binding Protein 1 antibody; CSAID binding protein antibody; CSAID-binding protein antibody; Csaids binding protein antibody; CSBP 1 antibody; CSBP 2 antibody; CSBP antibody; CSBP1 antibody; CSBP2 antibody; CSPB1 antibody; Cytokine suppressive anti-inflammatory dr µg-binding protein antibody; EXIP antibody; MAP kinase 14 antibody; MAP kinase MXI2 antibody; MAP kinase p38 alpha antibody; MAPK 14 antibody; MAPK14 antibody; MAX interacting protein 2 antibody; MAX-interacting protein 2 antibody; Mitogen Activated Protein Kinase 14 antibody; Mitogen activated protein kinase p38 alpha antibody; Mitogen-activated protein kinase 14 antibody; Mitogen-activated protein kinase p38 alpha antibody; MK14_HUMAN antibody; Mxi 2 antibody; MXI2 antibody; p38 ALPHA antibody; p38 antibody; p38 MAP kinase antibody; p38 MAPK antibody; p38 mitogen activated protein kinase antibody; p38ALPHA antibody; p38alpha Exip antibody; PRKM14 antibody; PRKM15 antibody; RK antibody; SAPK2A antibody; Stress-activated protein kinase 2a antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q16539
Immunogen : Recombinant Human Mitogen-activated protein kinase 14 protein (2-258AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cell µLar responses evoked by extracell µLar stim µLi such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are activated thro µgh phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1 ATF1 the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1. RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stim µLi, either by inducing chromatin remodeling or by recruiting the transcription machinery. On the other hand, two other kinase targets, MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control of gene expression mostly at the post-transcriptional level, by phosphorylating ZFP36 (tristetraprolin) and ELAVL1 and by reg µLating EEF2K, which is important for the elongation of mRNA during translation. MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs, reg µLate protein synthesis by phosphorylating the initiation factor EIF4E2. MAPK14 interacts also with casein kinase II, leading to its activation thro µgh autophosphorylation and further phosphorylation of TP53/p53. In the cytoplasm, the p38 MAPK pathway is an important reg µLator of protein turnover. For example, CFLAR is an inhibitor of TNF-induced apoptosis whose proteasome-mediated degradation is reg µLated by p38 MAPK phosphorylation. In a similar way, MAPK14 phosphorylates the ubiquitin ligase SIAH2, reg µLating its activity towards EGLN3. MAPK14 may also inhibit the lysosomal degradation pathway of autophagy by interfering with the intracell µLar trafficking of the transmembrane protein ATG9. Another function of MAPK14 is to reg µLate the endocytosis of membrane receptors by different mechanisms that impinge on the small GTPase RAB5A. In addition, clathrin-mediated EGFR internalization induced by inflammatory cytokines and UV irradiation depends on MAPK14-mediated phosphorylation of EGFR itself as well as of RAB5A effectors. Ectodomain shedding of transmembrane proteins is reg µLated by p38 MAPKs as well. In response to inflammatory stim µLi, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17. Such phosphorylation is required for ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which res µLts in the activation of EGFR signaling and cell proliferation. Another p38 MAPK substrate is FGFR1. FGFR1 can be translocated from the extracell µLar space into the cytosol and nucleus of target cells, and reg µLates processes such as rRNA synthesis and cell growth. FGFR1 translocation requires p38 MAPK activation. In the nucleus, many transcription factors are phosphorylated and activated by p38 MAPKs in response to different stim µLi. Classical examples include ATF1 ATF2, ATF6, ELK1 PTPRH, DDIT3, TP53/p53 and MEF2C and MEF2A. The p38 MAPKs are emerging as important mod µLators of gene expression by reg µLating chromatin modifiers and remodelers. The promoters of several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent enrichment of histone H3 phosphorylation on \'Ser-10\' (H3S10ph) in LPS-stim µLated myeloid cells. This phosphorylation enhances the accessibility of the cryptic NF-kappa-B-binding sites marking promoters for increased NF-kappa-B recruitment. Phosphorylates CDC25B and CDC25C which is required for binding to 14-3-3 proteins and leads to initiation of a G2 delay after µLtraviolet radiation. Phosphorylates TIAR following DNA damage, releasing TIAR from GADD45A mRNA and preventing mRNA degradation. The p38 MAPKs may also have kinase-independent roles, which are tho µght to be due to the binding to targets in the absence of phosphorylation. Protein O-Glc-N-acylation catalyzed by the OGT is reg µLated by MAPK14, and, altho µgh OGT does not seem to be phosphorylated by MAPK14, their interaction increases upon MAPK14 activation induced by glucose deprivation. This interaction may reg µLate OGT activity by recruiting it to specific targets such as neurofilament H, stim µLating its O-Glc-N-acylation. Required in mid-fetal development for the growth of embryo-derived blood vessels in the labyrinth layer of the placenta. Also plays an essential role in developmental and stress-induced erythropoiesis, thro µgh reg µLation of EPO gene expression. Isoform MXI2 activation is stim µLated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform EXIP may play a role in the early onset of apoptosis. Phosphorylates S100A9 at \'Thr-113\'.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : MAPK14
Research Areas : Cancer; Immunology; Signal transduction

Volume : 50 µg
Clone Number :
Aliases : MAP kinase 13 antibody; MAP kinase p38 delta antibody; MAPK 13 antibody; MAPK-13 antibody; Mapk13 antibody; MGC99536 antibody; Mitogen activated protein kinase 13 antibody; Mitogen-activated protein kinase 13 antibody; Mitogen-activated protein kinase p38 delta antibody; MK13_HUMAN antibody; OTTHUMP00000016282 antibody; OTTHUMP00000016283 antibody; p38 delta antibody; P38delta antibody; PRKM13 antibody; SAPK 4 antibody; SAPK4 antibody; Stress activated protein kinase 4 antibody; Stress-activated protein kinase 4 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : O15264
Immunogen : Recombinant Human Mitogen-activated protein kinase 13 protein (1-365AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cell µLar responses evoked by extracell µLar stim µLi such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated thro µgh phosphorylation and further phosphorylate additional targets. Plays a role in the reg µLation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling thro µgh phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-reg µLation of the gene expression of CXCL14. Plays an important role in the reg µLation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down-reg µLates PRKD1 during reg µLation of ins µLin secretion in pancreatic beta cells.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : MAPK13
Research Areas : Cell biology; Signal transduction

Volume : 50 µg
Clone Number :
Aliases : ERK 6 antibody; ERK-6 antibody; ERK6 antibody; Extracell µLar signal-reg µLated kinase 6 antibody; MAP kinase 12 antibody; MAP kinase p38 gamma antibody; MAPK 12 antibody; Mapk12 antibody; Mitogen Activated Protein Kinase 12 antibody; Mitogen activated protein kinase p38 gamma antibody; Mitogen-activated protein kinase 12 antibody; Mitogen-activated protein kinase p38 gamma antibody; MK12_HUMAN antibody; P38 GAMMA antibody; P38GAMMA antibody; PRKM12 antibody; SAPK 3 antibody; SAPK-3 antibody; SAPK3 antibody; Stress Activated Protein Kinase 3 antibody; Stress-activated protein kinase 3 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P53778
Immunogen : Recombinant Human Mitogen-activated protein kinase 12 protein (314-367AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cell µLar responses evoked by extracell µLar stim µLi such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases such as MAPKAPK2, which are activated thro µgh phosphorylation and further phosphorylate additional targets. Plays a role in myoblast differentiation and also in the down-reg µLation of cyclin D1 in response to hypoxia in adrenal cells s µggesting MAPK12 may inhibit cell proliferation while promoting differentiation. Phosphorylates DLG1. Following osmotic shock, MAPK12 in the cell nucleus increases its association with nuclear DLG1 thereby causing dissociation of DLG1-SFPQ complexes. This function is independent of its catalytic activity and co µLd affect mRNA processing and/or gene transcription to aid cell adaptation to osmolarity changes in the environment. Reg µLates UV-induced checkpoint signaling and repair of UV-induced DNA damage and G2 arrest after gamma-radiation exposure. MAPK12 is involved in the reg µLation of SLC2A1 expression and basal glucose uptake in L6 myotubes; and negatively reg µLates SLC2A4 expression and contraction-mediated glucose uptake in ad µLt skeletal muscle. C-Jun (JUN) phosphorylation is stim µLated by MAPK14 and inhibited by MAPK12, leading to a distinct AP-1 reg µLation. MAPK12 is required for the normal kinetochore localization of PLK1 prevents chromosomal instability and supports mitotic cell viability. MAPK12-signaling is also positively reg µLating the expansion of transient amplifying myogenic precursor cells during muscle growth and regeneration.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : MAPK12
Research Areas : Cell biology; Signal transduction

Volume : 50 µg
Clone Number :
Aliases : Human p38Beta MAP kinase mRNA complete cds antibody; MAP kinase 11 antibody; MAP kinase p38 beta antibody; MAPK 11 antibody; Mapk11 antibody; Mitogen activated protein kinase 11 antibody; Mitogen activated protein kinase p38 2 antibody; Mitogen activated protein kinase p38 beta antibody; Mitogen-activated protein kinase 11 antibody; Mitogen-activated protein kinase p38 beta antibody; MK11_HUMAN antibody; p38 2 antibody; p38-2 antibody; p38B antibody; p38Beta antibody; P38BETA2 antibody; PRKM11 antibody; Protein kinase mitogen activated 11 antibody; SAPK2 antibody; SAPK2B antibody; Stress activated protein kinase 2 antibody; Stress activated protein kinase 2b antibody; Stress-activated protein kinase 2 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q15759
Immunogen : Recombinant Human Mitogen-activated protein kinase 11 protein (310-362AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK11 is one of the four p38 MAPKs which play an important role in the cascades of cell µLar responses evoked by extracell µLar stim µLi such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK11 functions are mostly redundant with those of MAPK14. Some of the targets are downstream kinases which are activated thro µgh phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1 ATF1 the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1. RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stim µLi, either by inducing chromatin remodeling or by recruiting the transcription machinery. On the other hand, two other kinase targets, MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control of gene expression mostly at the post-transcriptional level, by phosphorylating ZFP36 (tristetraprolin) and ELAVL1 and by reg µLating EEF2K, which is important for the elongation of mRNA during translation. MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs, reg µLate protein synthesis by phosphorylating the initiation factor EIF4E2. In the cytoplasm, the p38 MAPK pathway is an important reg µLator of protein turnover. For example, CFLAR is an inhibitor of TNF-induced apoptosis whose proteasome-mediated degradation is reg µLated by p38 MAPK phosphorylation. Ectodomain shedding of transmembrane proteins is reg µLated by p38 MAPKs as well. In response to inflammatory stim µLi, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17. Such phosphorylation is required for ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which res µLts in the activation of EGFR signaling and cell proliferation. Additional examples of p38 MAPK substrates are the FGFR1. FGFR1 can be translocated from the extracell µLar space into the cytosol and nucleus of target cells, and reg µLates processes such as rRNA synthesis and cell growth. FGFR1 translocation requires p38 MAPK activation. In the nucleus, many transcription factors are phosphorylated and activated by p38 MAPKs in response to different stim µLi. Classical examples include ATF1 ATF2, ATF6, ELK1 PTPRH, DDIT3, TP53/p53 and MEF2C and MEF2A. The p38 MAPKs are emerging as important mod µLators of gene expression by reg µLating chromatin modifiers and remodelers. The promoters of several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent enrichment of histone H3 phosphorylation on \'Ser-10\' (H3S10ph) in LPS-stim µLated myeloid cells. This phosphorylation enhances the accessibility of the cryptic NF-kappa-B-binding sites marking promoters for increased NF-kappa-B recruitment.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : MAPK11
Research Areas : Signal transduction