Volume : 50 µg
Clone Number :
Aliases : Aryl hydrocarbon hydroxylase antibody; CP1B antibody; CP1B1_HUMAN antibody; Cyp1b1 antibody; CYPIB1 antibody; Cytochrome P450 1B1 antibody; Cytochrome P450 family 1 subfamily B polypeptide 1 antibody; Cytochrome P450 subfamily I (dioxin inducible) polypeptide 1 (glaucoma 3 primary infantile) antibody; Flavoprotein linked monooxygenase antibody; GLC3A antibody; Microsomal monooxygenase antibody; P4501B1 antibody; Xenobiotic monooxygenase antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q16678
Immunogen : Recombinant Human Cytochrome P450 1B1 protein (282-409AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, retinoid and xenobiotics. Preferentially oxidizes 17beta-estradiol to the carcinogenic 4-hydroxy derivative, and a variety of procarcinogenic compounds to their activated forms, including polycyclic aromatic hydrocarbons. Promotes angiogenesis by removing cell µLar oxygenation products, thereby decreasing oxidative stress, release of antiangiogenic factor THBS2, then allowing endothelial cells migration, cell adhesion and capillary morphogenesis. These changes are concommitant with the endothelial nitric oxide synthase activity and nitric oxide synthesis. Plays an important role in the reg µLation of perivasc µLar cell proliferation, migration, and survival thro µgh mod µLation of the intracell µLar oxidative state and NF-kappa-B expression and/or activity, during angiogenesis. Contributes to oxidative homeostasis and µLtrastructural organization and function of trabec µLar meshwork tissue thro µgh mod µLation of POSTN expression.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : HRP
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : CYP1B1
Research Areas : Neuroscience; Cardiovasc µLar; Metabolism; Signal transduction