Volume : 50 µg
Clone Number :
Aliases : Dual specificity mitogen activated protein kinase kinase 6 antibody; Dual specificity mitogen-activated protein kinase kinase 6 antibody; MAP kinase kinase 6 antibody; MAP2K6 antibody; MAPK/ERK kinase 6 antibody; MAPKK 6 antibody; MAPKK6 antibody; MEK 6 antibody; MEK6 antibody; Mitogen Activated Protein Kinase Kinase 6 antibody; MKK 6 antibody; MKK6 antibody; MP2K6_HUMAN antibody; PRKMK6 antibody; protein kinase antibody; Protein kinase mitogen activated kinase 6 antibody; protein kinase, mitogen-activated, kinase 6 (MAP kinase kinase 6) antibody; SAPK kinase 3 antibody; SAPKK-3 antibody; SAPKK3 antibody; SKK3 antibody; Stress-activated protein kinase kinase 3 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P52564
Immunogen : Recombinant Human Dual specificity mitogen-activated protein kinase kinase 6 protein (1-334AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. With MAP3K3/MKK3, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 MAPK11 MAPK12, MAPK13 and MAPK14 and plays an important role in the reg µLation of cell µLar responses to cytokines and all kinds of stresses. Especially, MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 and MAPK13 induced by environmental stress, whereas MAP2K6/MKK6 is the major MAPK11 activator in response to TNF. MAP2K6/MKK6 also phosphorylates and activates PAK6. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Nuclear targets of p38 MAP kinase include the transcription factors ATF2 and ELK1. Within the p38 MAPK signal transduction pathway, MAP3K6/MKK6 mediates phosphorylation of STAT4 thro µgh MAPK14 activation, and is therefore required for STAT4 activation and STAT4-reg µLated gene expression in response to IL-12 stim µLation. The pathway is also crucial for IL-6-induced SOCS3 expression and down-reg µLation of IL-6-mediated gene induction; and for IFNG-dependent gene transcription. Has a role in osteoclast differentiation thro µgh NF-kappa-B transactivation by TNFSF11 and in endochondral ossification and since SOX9 is another likely downstream target of the p38 MAPK pathway. MAP2K6/MKK6 mediates apoptotic cell death in thymocytes. Acts also as a reg µLator for melanocytes dendricity, thro µgh the mod µLation of Rho family GTPases.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : HRP
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : MAP2K6
Research Areas : Cell biology; Immunology; Signal transduction