Volume : 50 µg
Protein Type : Target proteins
Product Grade : For Research Use.
Tag : C-6His
Species : Human
Expressed In : Human Cells
Note : Usually in stock. Smaller quantities and volume discounts are available. For further information, please contact us.

Volume : 50 µg
Protein Type : Other proteins
Product Grade : For Research Use.
Tag : C-Fc-6His
Species : Human
Expressed In : Human Cells
Note : Usually in stock. Smaller quantities and volume discounts are available. For further information, please contact us.

Volume : 50 µg
Protein Type : Target proteins
Product Grade : For Research Use.
Tag : C-Fc
Species : Human
Expressed In : Human Cells
Note : Usually in stock. Smaller quantities and volume discounts are available. For further information, please contact us.

Volume : 50 µg
Protein Type : Target proteins
Product Grade : For Research Use.
Tag : C-Fc
Species : Human
Expressed In : Human Cells
Note : Usually in stock. Smaller quantities and volume discounts are available. For further information, please contact us.

Volume : 100 µg
Purification : Immunogen affinity purified
Form : liquid
Purity : 95% as determined by SDS-PAGE
Host : Rabbit
Clonality : polyclonal Ab
Clone ID :
Isotype : IgG
Storage : PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)
Background : Anaplastic Lymphoma Kinase (ALK), also known as CD246, is a 220 kDa transmembrane glycoprotein that is primarily expressed in the developing nervous system. ALK contains one LDL Receptor (LDLR) class A domain, two meprin/A5-protein/PTPmu (MAM) domains, and a cytoplasmic kinase domain. Chromosomal translocation involving ALK and the nucleolar NPM protein res µLt in a cytoplasmic fusion protein that exists as a dimer. The kinase domain in NPM-ALK is constitutively active and participates in cell µLar transformation. ALK translocations are found in a variety of tumors. Within the extracell µLar domain, human and mouse ALK share 88% amino acid sequence identity.
Immunogen : anaplastic lymphoma receptor tyrosine kinase
Aliases : ALK, ALK tyrosine kinase receptor, ALK,CD246, Anaplastic lymphoma kinase, CD246, TFG/ALK
Observed MW : 140-220 kDa
Uniprot ID : Q9UM73
Reactivity : Human, Mouse, Rat
Application : ELISA, IHC, WB
Recommended dilution : WB : 1 : 500-1 : 2000; IHC : 1 : 20-1 : 200
Gene ID : 238
Research Area : Signal Transduction, Metabolism, Immunology, Cancer, Developmental biology, Neuroscience

Volume : 50 µg
Clone Number :
Aliases : Alk antibody; ALK tyrosine kinase receptor antibody; ALK/EML4 fusion gene; included antibody; ALK/NPM1 fusion gene; included antibody; ALK_HUMAN antibody; anaplastic lymphoma kinase (Ki-1) antibody; Anaplastic lymphoma kinase antibody; Anaplastic lymphoma kinase Ki1 antibody; anaplastic lymphoma receptor tyrosine kinase antibody; CD 246 antibody; CD246 antibody; CD246 antigen antibody; EC 2.7.10.1 antibody; Ki 1 antibody; Ki1 antibody; mutant anaplastic lymphoma kinase antibody; NBLST 3 antibody; NBLST3 antibody; Tcrz antibody; TFG/ALK antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q9UM73
Immunogen : Recombinant Human ALK tyrosine kinase receptor protein (1402-1604AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, thro µgh specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1 as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Acts as a receptor for ligands pleiotrophin (PTN), a secreted growth factor, and midkine (MDK), a PTN-related factor, thus participating in PTN and MDK signal transduction. PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and reg µLation of cell proliferation. MDK-binding induces phosphorylation of the ALK target ins µLin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, res µLting also in cell proliferation induction. Drives NF-kappa-B activation, probably thro µgh IRS1 and the activation of the AKT serine/threonine kinase. Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : HRP
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : ALK
Research Areas : Neuroscience; Cancer; Tags & Cell Markers

Volume : 50 µg
Clone Number :
Aliases : Alk antibody; ALK tyrosine kinase receptor antibody; ALK/EML4 fusion gene; included antibody; ALK/NPM1 fusion gene; included antibody; ALK_HUMAN antibody; anaplastic lymphoma kinase (Ki-1) antibody; Anaplastic lymphoma kinase antibody; Anaplastic lymphoma kinase Ki1 antibody; anaplastic lymphoma receptor tyrosine kinase antibody; CD 246 antibody; CD246 antibody; CD246 antigen antibody; EC 2.7.10.1 antibody; Ki 1 antibody; Ki1 antibody; mutant anaplastic lymphoma kinase antibody; NBLST 3 antibody; NBLST3 antibody; Tcrz antibody; TFG/ALK antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q9UM73
Immunogen : Recombinant Human ALK tyrosine kinase receptor protein (1402-1604AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, thro µgh specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1 as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Acts as a receptor for ligands pleiotrophin (PTN), a secreted growth factor, and midkine (MDK), a PTN-related factor, thus participating in PTN and MDK signal transduction. PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and reg µLation of cell proliferation. MDK-binding induces phosphorylation of the ALK target ins µLin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, res µLting also in cell proliferation induction. Drives NF-kappa-B activation, probably thro µgh IRS1 and the activation of the AKT serine/threonine kinase. Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : ALK
Research Areas : Neuroscience; Cancer; Tags & Cell Markers

Volume : 50 µg
Clone Number :
Aliases : Alk antibody; ALK tyrosine kinase receptor antibody; ALK/EML4 fusion gene; included antibody; ALK/NPM1 fusion gene; included antibody; ALK_HUMAN antibody; anaplastic lymphoma kinase (Ki-1) antibody; Anaplastic lymphoma kinase antibody; Anaplastic lymphoma kinase Ki1 antibody; anaplastic lymphoma receptor tyrosine kinase antibody; CD 246 antibody; CD246 antibody; CD246 antigen antibody; EC 2.7.10.1 antibody; Ki 1 antibody; Ki1 antibody; mutant anaplastic lymphoma kinase antibody; NBLST 3 antibody; NBLST3 antibody; Tcrz antibody; TFG/ALK antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q9UM73
Immunogen : Recombinant Human ALK tyrosine kinase receptor protein (1402-1604AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, thro µgh specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1 as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Acts as a receptor for ligands pleiotrophin (PTN), a secreted growth factor, and midkine (MDK), a PTN-related factor, thus participating in PTN and MDK signal transduction. PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and reg µLation of cell proliferation. MDK-binding induces phosphorylation of the ALK target ins µLin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, res µLting also in cell proliferation induction. Drives NF-kappa-B activation, probably thro µgh IRS1 and the activation of the AKT serine/threonine kinase. Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : ALK
Research Areas : Neuroscience; Cancer; Tags & Cell Markers

Volume : 100 µL
Host : Rabbit
Clonality : polyclonal Ab
Isotype : IgG
GeneName : ALK
GeneID : 238
Uniprot : Q9UM73
Specificity : ALK Antibody detects endogenous levels of total ALK.
Immunogen : A syntheVolumed peptide derived from human ALK, corresponding to a region within C-terminal amino acids.
Storage : Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Reactivity : Human,Mouse
Prediction : Pig,Zebrafish,Bovine,Rabbit,Dog
Application : WB,IF/ICC,ELISA(peptide)
Dilution : WB 1 : 500-1 : 2000, IF/ICC 1 : 100-1 : 500, ELISA(peptide) 1 : 20000-1 : 40000
Conj µgate : Unconj µgated
RRID : AB_2835300
An Introduction to Blocking Peptides : A superior strategy for validation of antibody binding is the use of blocking peptides. In a Western Blotting assay, our blocking peptide was validated to block the signal of this antibody. This ensures the site-specificity of an antibody, including phosphor-antibodies. In the case of the phosphor- antibodies, the antibodies can and will only recognize the phosphorylated target protein at the corresponding site, not the non-phosphorylated target protein or target protein phosphorylated at a different site.
Cat# Blocking Peptide : AF6489-BP
Des# Blocking Peptide : ALK Blocking peptide
Blocking Peptide Price : $549 CAD

Volume : 50 µL
Clone Number :
Aliases : algLAlginate lyase antibody; EC 4.2.2.3 antibody; Poly(beta-D-mannuronate) lyase antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Azotobacter vinelandii
UniProt ID : O52195
Immunogen : Recombinant Azotobacter vinelandii Alginate lyase protein (24-374AA)
Raised in : Rabbit
Species Reactivity : Azotobacter vinelandii
Tested Applications : ELISA
Background : Catalyzes the depolymerization of alginate by cleaving the beta-14 glycosidic bond between two adjacent s µgar residues via a beta-elimination mechanism. Splits ManA-ManA and ManA-G µLA bonds, but not G µLA-ManA or G µLA-G µLA bonds. Also cleaves acetylated residues (PubMed : 9683471). May serve to degrade mislocalized alginate that is trapped in the periplasmic space (By similarity).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : HRP
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : algL
Research Areas : Others

Volume : 50 µL
Clone Number :
Aliases : algLAlginate lyase antibody; EC 4.2.2.3 antibody; Poly(beta-D-mannuronate) lyase antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Azotobacter vinelandii
UniProt ID : O52195
Immunogen : Recombinant Azotobacter vinelandii Alginate lyase protein (24-374AA)
Raised in : Rabbit
Species Reactivity : Azotobacter vinelandii
Tested Applications :
Background : Catalyzes the depolymerization of alginate by cleaving the beta-14 glycosidic bond between two adjacent s µgar residues via a beta-elimination mechanism. Splits ManA-ManA and ManA-G µLA bonds, but not G µLA-ManA or G µLA-G µLA bonds. Also cleaves acetylated residues (PubMed : 9683471). May serve to degrade mislocalized alginate that is trapped in the periplasmic space (By similarity).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : algL
Research Areas : Others