Volume : 100 µg
Purification : Immunogen affinity purified
Form : liquid
Purity : 95% as determined by SDS-PAGE
Host : Rabbit
Clonality : polyclonal Ab
Clone ID :
Isotype : IgG
Storage : PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20? for 12 months (Avoid repeated freeze / thaw cycles.)
Background : The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains : the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stim µLates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal b µLbar musc µLar atrophy (SBMA, also known as Kennedy's disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Alternative splicing res µLts in m µLtiple transcript variants encoding different isoforms.
Immunogen : androgen receptor
Aliases : AIS, androgen receptor, AR, DHTR, Dihydrotestosterone receptor, HUMARA, HYSP1 KD, NR3C4, SBMA, SMAX1 TFM
Observed MW : 100 kDa
Uniprot ID : P10275
Reactivity : Human, Mouse
Application : ELISA, WB, IHC
Recommended dilution : WB : 1 : 500 - 1 : 2000; IHC : 1 : 50 - 1 : 100
Gene ID : 367
Research Area : Signal Transduction, Metabolism, Cancer, Immunology, Neuroscience