Volume : 50 µg
Clone Number :
Aliases : grb 10 antibody; GRB IR antibody; grb-10 antibody; GRB10 adapter protein antibody; GRB10 adaptor protein antibody; GRB10 antibody; GRB10_HUMAN antibody; GRBIR antibody; Growth factor receptor bound protein 10 antibody; Growth factor receptor-bound protein 10 antibody; Ins µLin receptor binding protein antibody; Ins µLin receptor binding protein GRB IR antibody; Ins µLin receptor-binding protein Grb-IR antibody; IRBP antibody; KIAA0207 antibody; Maternally expressed gene 1 antibody; MEG1 antibody; RSS antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q13322
Immunogen : Recombinant Human Growth factor receptor-bound protein 10 protein (15-180AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Adapter protein which mod µLates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the ins µLin (INSR) and ins µLin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms : interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to ins µLin stim µLation. Blocks association between INSR and IRS1 and IRS2 and prevents ins µLin-stim µLated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating ins µLin-stim µLated ubiquitination of INSR, leading to proteasomal degradation. Negatively reg µLates Wnt signaling by interacting with LRP6 intracell µLar portion and interfering with the binding of AXIN1 to LRP6. Positive reg µLator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : GRB10
Research Areas : Signal transduction