Volume : 50 µg
Clone Number :
Aliases : CEPR antibody; Chemoattractant receptor-like 2 antibody; Chemokine receptor-like 2 antibody; CMKRL2 antibody; Constitutively expressed peptide like receptor antibody; DRY12 antibody; FEG 1 antibody; FEG-1 antibody; Flow-induced endothelial G protein-coupled receptor antibody; Flow-induced endothelial G-protein coupled receptor 1 antibody; G protein-coupled receptor 30 antibody; G-protein coupled estrogen receptor 1 antibody; G-protein coupled receptor 30 antibody; GPCR-BR antibody; Gper antibody; GPER_HUMAN antibody; GPER1 antibody; GPR30 antibody; IL8-related receptor DRY12 antibody; Lergu antibody; LERGU2 antibody; leucine rich protein in GPR30 3'UTR antibody; LYGPR antibody; Lymphocyte-derived G-protein coupled receptor antibody; Membrane estrogen receptor antibody; mER antibody; MGC99678 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q99527
Immunogen : Recombinant Human G-protein coupled estrogen receptor 1 protein (1-62AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : G-protein coupled estrogen receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracell µLar signaling pathways. Stim µLates cAMP production, calcium mobilization and tyrosine kinase Src inducing the release of heparin-bound epidermal growth factor (HB-EGF) and subsequent transactivation of the epidermal growth factor receptor (EGFR), activating downstream signaling pathways such as PI3K/Akt and ERK/MAPK. Mediates pleiotropic functions among others in the cardiovasc µLar, endocrine, reproductive, immune and central nervous systems. Has a role in cardioprotection by reducing cardiac hypertrophy and perivasc µLar fibrosis in a RAMP3-dependent manner. Reg µLates arterial blood pressure by stim µLating vasodilation and reducing vasc µLar smooth muscle and microvasc µLar endothelial cell proliferation. Plays a role in blood glucose homeostasis contributing to the ins µLin secretion response by pancreatic beta cells. Triggers mitochondrial apoptosis during pachytene spermatocyte differentiation. Stim µLates uterine epithelial cell proliferation. Enhances uterine contractility in response to oxytocin. Contributes to thymic atrophy by inducing apoptosis. Attenuates TNF-mediated endothelial expression of leukocyte adhesion molec µLes. Promotes neuritogenesis in developing hippocampal neurons. Plays a role in acute neuroprotection against NMDA-induced excitotoxic neuronal death. Increases firing activity and intracell µLar calcium oscillations in luteinizing hormone-releasing hormone (LHRH) neurons. Inhibits early osteoblast proliferation at growth plate during skeletal development. Inhibits mature adipocyte differentiation and lipid accum µLation. Involved in the recruitment of beta-arrestin 2 ARRB2 at the plasma membrane in epithelial cells. Functions also as a receptor for aldosterone mediating rapid reg µLation of vasc µLar contractibility thro µgh the PI3K/ERK signaling pathway. Involved in cancer progression reg µLation. Stim µLates cancer-associated fibroblast (CAF) proliferation by a rapid genomic response thro µgh the EGFR/ERK transduction pathway. Associated with EGFR, may act as a transcription factor activating growth reg µLatory genes (c-fos, cyclin D1). Promotes integrin alpha-5/beta-1 and fibronectin (FN) matrix assembly in breast cancer cells.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : GPER1
Research Areas : Epigenetics and Nuclear Signaling; Neuroscience; Metabolism; Signal transduction