Volume : 50 µg
Clone Number :
Aliases : GPR18 antibody; GPCRWN-arachidonyl glycine receptor antibody; NAGly receptor antibody; G-protein coupled receptor 18 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q14330
Immunogen : Recombinant Human N-arachidonyl glycine receptor protein (290-331AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Receptor for endocannabinoid N-arachidonyl glycine (NAGly) (PubMed : 16844083, PubMed : 24762058, PubMed : 27572937). However, conflicting res µLts about the role of NAGly as an agonist are reported (PubMed : 27018161). Can also be activated by plant-derived and synthetic cannabinoid agonists (PubMed : 24762058). The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase (PubMed : 16844083). May contribute to reg µLation of the immune system. Is required for normal homeostasis of CD8+ subsets of intraepithelial lymphocytes (IELs) (CD8alphaalpha and CD8alphabeta IELs)in small intstine by supporting preferential migration of CD8alphaalpha T-cells to intraepithelial compartment over lamina propria compartment, and by mediating their reconstitution into small intestine after bone marrow transplant (By similarity). Plays a role in hypotensive responses, mediating reduction in intraoc µLar and blood pressure (By similarity). Mediates NAGly-induced process of reorganization of actin filaments and induction of acrosomal exocytosis (PubMed : 27572937).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : GPR18
Research Areas : Neuroscience; Signal transduction