Volume : 50 µg
Clone Number :
Aliases : Checkpoint with forkhead and ring finger domains antibody; Checkpoint with forkhead and RING finger domains protein antibody; Chfr antibody; CHFR_HUMAN antibody; E3 ubiquitin protein ligase CHFR antibody; E3 ubiquitin-protein ligase CHFR antibody; EC 6.3.2. antibody; FLJ10796 antibody; FLJ33629 antibody; RING finger protein 196 antibody; RNF 116 antibody; RNF 196 antibody; RNF116 antibody; RNF196 antibody; Ubiquitin ligase protein antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q96EP1
Immunogen : Recombinant Human E3 ubiquitin-protein ligase CHFR protein (141-422AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtub µLe poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtub µLe poisons by mediating the \\\'Lys-48\\\'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURKA and PLK1. Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1 leading to its degradation. May also promote the formation of \\\'Lys-63\\\'-linked polyubiquitin chains and functions with the specific ubiquitin-conj µgating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at \\\'Lys-63\\\' are usually not targeted for degradation, but are rather involved in signaling cell µLar stress.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : CHFR
Research Areas : Epigenetics and Nuclear Signaling; Cancer; Cell biology