Volume : 100 µL
Clone Number :
Aliases :
Product Type : Monoclonal Antibody
Immunogen Species : Human
UniProt ID : P01732
Immunogen : Recombinant Protein
Raised in : Mouse
Species Reactivity : Human
Tested Applications : ELISA,IF,FC;Recommended dilution : IF : 1 : 100-1 : 200
Background : COV8 reacts with the 32 kDa a chain of CD8. This molec µLe is expressed on the T suppressor/cytotoxic cell pop µLation (which comprises about 1/3 of the peripheral blood T lymphocytes total pop µLation) and with most of thymocytes, as well as a subset of NK cells. CD8 expresses as either a heterodimer with the CD8b chain (CD8ab) or as a homodimer (CD8aa or CD8bb). CD8 acts as a co-receptor with MHC Class I restricted TCRs in antigen recognition. CD8 function is important for positive selection of MHC Class I restricted CD8+ T cells during T cell development.* Ratio of CD4 and CD8 is important for monitor of HIV infection.1. Engleman EG et al. (1981) J Exp Med 153 : 193-198.2. Haynes, B et al. (1986) Leukocyte Typing II : Human T lymphocytes. New York : Sprimger-Verlag; 3-30.3. Parnes, JR. et al. (1989). Adv. Immunol. 44,256-311.4. Bikah G. et al. (1996). Science 274 : 1906.
Clonality : Monoclonal
Isotype : IgG1
Purification Method : Affinity purified
Conj µgate : Non-conj µgated
Buffer : Phosphate-buffered solution, pH 7.4, containing 0.09% sodium azide and 0.2% (w/v) BSA
Form : liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : CD8A
Research Areas : Immunology