Volume : 50 µg
Clone Number :
Aliases : C1orf28 antibody; CDC 73 antibody; Cdc73 antibody; CDC73_HUMAN antibody; Cell division cycle 73 antibody; Cell division cycle 73 Paf1/RNA polymerase II complex component homolog antibody; Cell division cycle 73 Paf1/RNA polymerase II complex component like protein antibody; Cell division cycle protein 73 homolog antibody; FIHP antibody; FLJ23316 antibody; HPT JT antibody; HPTJT antibody; HRPT 2 antibody; HRPT1 antibody; HRPT2 antibody; Hyperparathyroidism 2 (with jaw tumor) antibody; Hyperparathyroidism 2 antibody; Hyperparathyroidism 2 protein antibody; HYX antibody; Paf1/RNA polymerase II complex component antibody; Parafibromin antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q6P1J9
Immunogen : Recombinant Human Parafibromin protein (74-346AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. May be involved in cell cycle progression thro µgh the reg µLation of cyclin D1/PRAD1 expression. Component of the PAF1 complex (PAF1C) which has m µLtiple functions during transcription by RNA polymerase II and is implicated in reg µLation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II thro µgh interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stim µLates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis thro µgh association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably thro µgh association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby reg µLating gene transcription. Connects PAF1C with the cleavage and polyadenylation specificity factor (CPSF) complex and the cleavage stim µLation factor (CSTF) complex, and with Wnt signaling. Involved in polyadenylation of mRNA precursors.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : CDC73
Research Areas : Epigenetics and Nuclear Signaling; Cancer