Volume : 50 µg
Clone Number :
Aliases : 6030441H18Rik antibody; Coiled coil domain containing protein MTMR15 antibody; DKFZp451H236 antibody; DKFZp686K16147 antibody; FAN1 antibody; FAN1_HUMAN antibody; FANCD2 and FANCI associated nuclease 1 antibody; FANCD2/FANCI associated nuclease 1 antibody; FANCD2/FANCI-associated nuclease 1 antibody; Fanconi associated nuclease 1 antibody; Fanconi-associated nuclease 1 antibody; hFAN1 antibody; KIAA1018 antibody; KMIN antibody; MTMR 15 antibody; MTMR15 antibody; Myotub µLarin related protein 15 antibody; Myotub µLarin-related protein 15 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q9Y2M0
Immunogen : Recombinant Human Fanconi-associated nuclease 1 protein (167-373AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates (PubMed : 20603015, PubMed : 20603016, PubMed : 20603073, PubMed : 20671156, PubMed : 24981866, PubMed : 25430771). Not involved in DNA double-strand breaks resection (PubMed : 20603015, PubMed : 20603016). Acts as a 5\'-3\' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand thro µgh flanking incisions. Probably keeps excising with 3\'-flap annealing until it reaches and unhooks the ICL (PubMed : 25430771). Acts at sites that have a 5\'-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is a µgmented by a 3\' flap (PubMed : 25430771). Also has endonuclease activity toward 5\'-flaps (PubMed : 20603015, PubMed : 20603016, PubMed : 24981866).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : FAN1
Research Areas : Epigenetics and Nuclear Signaling