Biotinilated

Volume : 50 µg
Clone Number :
Aliases : CDA12 antibody; HLA 5.4 antibody; HLA class I histocompatibility antigen; alpha chain F antibody; HLA class I molec µLe antibody; HLA F antigen antibody; HLA-CDA12 antibody; HLA-F antibody; HLAF antibody; HLAF_HUMAN antibody; Leukocyte antigen F antibody; MHC class I antigen F antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P30511
Immunogen : Recombinant Human HLA class I histocompatibility antigen, alpha chain F protein (194-303AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Involved in the presentation of foreign antigens to the immune system.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : HLA-F
Research Areas : Immunology

Volume : 50 µg
Clone Number :
Aliases : HLA-E antibody; HLA-6.2 antibody; HLAEHLA class I histocompatibility antigen antibody; alpha chain E antibody; MHC class I antigen E) [Cleaved into : Soluble HLA class I histocompatibility antigen antibody; alpha chain E antibody; sHLA-E)] antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P13747
Immunogen : Recombinant Human HLA class I histocompatibility antigen, alpha chain E protein (33-261AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Non-classical major histocompatibility class Ib molec µLe involved in immune self-nonself discrimination. In complex with B2M/beta-2-microglob µLin binds nonamer self-peptides derived from the signal sequence of classical MHC class Ia molec µLes (VL9 peptides) (PubMed : 9754572, PubMed : 18083576, PubMed : 18339401). Peptide-bound HLA-E-B2M heterotrimeric complex primarily functions as a ligand for natural killer (NK) cell inhibitory receptor KLRD1-KLRC1 enabling NK cells to monitor the expression of other MHC class I molec µLes in healthy cells and to tolerate self (PubMed : 9754572, PubMed : 9486650, PubMed : 17179229, PubMed : 18083576). Upon cell µLar stress, preferentially binds signal sequence-derived peptides from stress-induced chaperones and is no longer recognized by NK cell inhibitory receptor KLRD1-KLRC1 res µLting in impaired protection from NK cells (PubMed : 12461076). Binds signal sequence-derived peptides from non-classical MHC class Ib HLA-G molec µLes and acts as a ligand for NK cell activating receptor KLRD1-KLRC2, likely playing a role in the generation and effector functions of adaptive NK cells and in maternal-fetal tolerance during pregnancy (PubMed : 9754572, PubMed : 30134159). Besides self-peptides, can also bind and present pathogen-derived peptides conformationally similar to VL9 peptides to alpha-beta T cell receptor (TCR) on unconventional CD8+ cytotoxic T cells, µLtimately triggering antimicrobial immune response (PubMed : 16474394, PubMed : 30087334).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : Antigen Affinity Purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : HLA-E
Research Areas : Immunology

Volume : 50 µg
Clone Number :
Aliases : DR 4 antibody; DR beta 4 chain antibody; DR4 antibody; DRB1 transplantation antigen antibody; DRB4 antibody; DRB4_HUMAN antibody; HLA class II histocompatibility antigen antibody; HLA class II histocompatibility antigen DR beta 4 chain antibody; HLA-DRB4 antibody; Human leucocyte antigen DRB4 antibody; Leukocyte antigen antibody; Major histocompatibility complex class II DR beta 4 antibody; MHC class II antigen DRB4 antibody; MHC class II antigen HLA DR beta antibody; MHC class2 antigen antibody; MHC HLA DR-beta chain antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P13762
Immunogen : Recombinant Human HLA class II histocompatibility antigen, DR beta 4 chain protein (30-227AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molec µLes are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molec µLes, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molec µLes and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molec µLe that presents an antigen, three MHC class II molec µLes (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molec µLes until primary high affinity antigenic peptides are bound. The MHC II molec µLe bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molec µLes is reg µLated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the reg µLation of antigen loading into MHC II molec µLes, increased acidification produces increased proteolysis and efficient peptide loading.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : HLA-DRB4
Research Areas : Immunology

Volume : 50 µg
Clone Number :
Aliases : DR beta 3 chain antibody; DR7 antibody; DRB3_HUMAN antibody; HLA class II histocompatibility antigen antibody; HLA class II histocompatibility antigen DR beta 3 chain antibody; HLA class II histocompatibility antigen DRB1 7 beta chain antibody; HLA DR3B antibody; HLA-DRB3 antibody; Human leucocyte antigen DRB3 antibody; Major histocompatibility complex class II DR beta 3 antibody; MGC117330 antibody; MHC class II antigen DR beta 3 chain antibody; MHC class II antigen DRB3 antibody; MHC class II HLA DR beta 3 chain antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P79483
Immunogen : Recombinant Human HLA class II histocompatibility antigen, DR beta 3 chain protein (111-227AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molec µLes are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molec µLes, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molec µLes and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molec µLe that presents an antigen, three MHC class II molec µLes (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molec µLes until primary high affinity antigenic peptides are bound. The MHC II molec µLe bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molec µLes is reg µLated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the reg µLation of antigen loading into MHC II molec µLes, increased acidification produces increased proteolysis and efficient peptide loading.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : HLA-DRB3
Research Areas : Immunology

Volume : 50 µg
Clone Number :
Aliases : HLA class II histocompatibility antigen, DRB1-3 chain (Clone P2-beta-3) (MHC class II antigen DRB1*3), HLA-DRB1
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P01912
Immunogen : Recombinant Human HLA class II histocompatibility antigen, DRB1-3 chain protein (31-266AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA, IHC; Recommended dilution : IHC : 1 : 20-1 : 200
Background : Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molec µLes are generated mostly by degradation of proteins that access the endocytic route; where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molec µLes; and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments; exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides; autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs; other cells of the gastrointestinal tract; such as epithelial cells; express MHC class II molec µLes and CD74 and act as APCs; which is an unusual trait of the GI tract. To produce a MHC class II molec µLe that presents an antigen; three MHC class II molec µLes (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form an heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs; CD74 undergoes a sequential degradation by various proteases; including CTSS and CTSL; leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molec µLes until primary high affinity antigenic peptides are bound. The MHC II molec µLe bound to a peptide is then transported to the cell membrane surface. In B-cells; the interaction between HLA-DM and MHC class II molec µLes is reg µLated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal miroenvironment has been implicated in the reg µLation of antigen loading into MHC II molec µLes; increased acidification produces increased proteolysis and efficient peptide loading.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : HLA-DRB1
Research Areas : Others

Volume : 50 µg
Clone Number :
Aliases : DASS-397D15.1 antibody; DR alpha chain antibody; DR alpha chain precursor antibody; DRA_HUMAN antibody; DRB1 antibody; DRB4 antibody; FLJ51114 antibody; Histocompatibility antigen HLA DR alpha antibody; Histocompatibility antigen HLA-DR alpha antibody; HLA class II histocompatibility antigen antibody; HLA class II histocompatibility antigen DR alpha chain antibody; HLA DR1B antibody; HLA DR3B antibody; HLA DRA antibody; HLA DRA1 antibody; HLA DRB1 antibody; HLA DRB3 antibody; HLA DRB4 antibody; HLA DRB5 antibody; HLA-DR histocompatibility type antibody; HLA-DRA antibody; HLADR4B antibody; HLADRA1 antibody; HLADRB antibody; Major histocompatibility complex class II DR alpha antibody; Major histocompatibility complex class II DR beta 1 antibody; Major histocompatibility complex class II DR beta 3 antibody; Major histocompatibility complex class II DR beta 4 antibody; Major histocompatibility complex class II DR beta 5 antibody; MGC117330 antibody; MHC cell surface glycoprotein antibody; MHC class II antigen DRA antibody; MHC II antibody; MLRW antibody; OTTHUMP00000029406 antibody; OTTHUMP00000029407 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P01903
Immunogen : Recombinant Human HLA class II histocompatibility antigen, DR alpha chain protein (28-254AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molec µLes are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molec µLes, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molec µLes and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molec µLe that presents an antigen, three MHC class II molec µLes (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molec µLes until primary high affinity antigenic peptides are bound. The MHC II molec µLe bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molec µLes is reg µLated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal miroenvironment has been implicated in the reg µLation of antigen loading into MHC II molec µLes, increased acidification produces increased proteolysis and efficient peptide loading.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : HLA-DRA
Research Areas : Immunology

Volume : 50 µg
Clone Number :
Aliases : CELIAC1 antibody; DQ beta 1 chain antibody; DQB1_HUMAN antibody; HLA class II histocompatibility antigen antibody; HLA class II histocompatibility antigen; DQ beta 1 chain antibody; HLA class II histocompatibility antigen; DQ beta 2 chain antibody; HLA DQB antibody; HLA DQB1 antibody; HLA-DQB1 antibody; HLA-DQB2 antibody; IDDM1 antibody; Lymphocyte antigen antibody; Major histocompatibility complex class II beta antibody; Major histocompatibility complex; class II; DQ beta 1 antibody; MHC class II antigen DQB1 antibody; MHC class II antigen HLA DQ beta 1 antibody; MHC class II DQ beta chain antibody; MHC class II HLA DQ beta glycoprotein antibody; MHC class2 antigen antibody; MHC DQ beta antibody; OTTHUMP00000029167 antibody; OTTHUMP00000178569 antibody; OTTHUMP00000178570 antibody; OTTHUMP00000178571 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P01920
Immunogen : Recombinant Human HLA class II histocompatibility antigen, DQ beta 1 chain protein (128-175AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molec µLes are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molec µLes, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molec µLes and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molec µLe that presents an antigen, three MHC class II molec µLes (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molec µLes until primary high affinity antigenic peptides are bound. The MHC II molec µLe bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molec µLes is reg µLated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the reg µLation of antigen loading into MHC II molec µLes, increased acidification produces increased proteolysis and efficient peptide loading.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : HLA-DQB1
Research Areas : Immunology

Volume : 50 µg
Clone Number :
Aliases : DQ(6) alpha chain antibody; DQA2_HUMAN antibody; DX alpha antibody; DX alpha chain antibody; HLA class II histocompatibility antigen antibody; HLA class II histocompatibility antigen DQ(6) alpha chain antibody; HLA class II histocompatibility antigen; DQ alpha 2 chain antibody; HLA DXA antibody; HLA-DQA1 antibody; HLA-DQA2 antibody; Major histocompatibility complex class II DQ alpha 2 antibody; MHC class II DQA2 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P01906
Immunogen : Recombinant Human HLA class II histocompatibility antigen, DQ alpha 2 chain protein (24-214AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molec µLes are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molec µLes, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molec µLes and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molec µLe that presents an antigen, three MHC class II molec µLes (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molec µLes until primary high affinity antigenic peptides are bound. The MHC II molec µLe bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molec µLes is reg µLated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal miroenvironment has been implicated in the reg µLation of antigen loading into MHC II molec µLes, increased acidification produces increased proteolysis and efficient peptide loading.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : HLA-DQA2
Research Areas : Immunology

Volume : 50 µg
Clone Number :
Aliases : CD antibody; CELIAC1 antibody; DC 1 alpha chain antibody; DC alpha antibody; DC-1 alpha chain antibody; DC-alpha antibody; DC1; included antibody; DQ alpha 1 chain antibody; DQ-A1 antibody; DQ-DRW9 alpha chain antibody; DQA1_HUMAN antibody; FLJ27088 antibody; FLJ27328 antibody; Gluten-sensitive enteropathy (celiac disease) antibody; GSE antibody; HLA class II histocompatibility antigen antibody; HLA class II histocompatibility antigen; DQ alpha 1 chain antibody; HLA class II histocompatibility antigen; DQ(W3) alpha chain antibody; HLA-DCA antibody; HLA-DQA antibody; HLA-DQA1 antibody; HLA-DQA1 major histocompatibility complex; class II; DQ alpha 1 antibody; HLADC histocompatibility type antibody; Immune response antigens HIa; included antibody; leucocyte antigen DQA1 antibody; leukocyte antigen alpha chain antibody; LOC100133678 antibody; LOC100507686 antibody; LOC100509457 antibody; Major histocompatibility complex; class II; DQ alpha 1 antibody; MGC149527 antibody; MHC class II antigen antibody; MHC class II DQA1 antibody; MHC class II HLA-D alpha glycoprotein antibody; MHC class II HLA-DQ alpha 1 antibody; MHC class II surface glycoprotein antibody; MHC HLA-DQ alpha antibody; OTTHUMP00000029141 antibody; OTTHUMP00000176885 antibody; OTTHUMP00000178551 antibody; OTTHUMP00000178552 antibody; OTTHUMP00000233817 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P01909
Immunogen : Recombinant Human HLA class II histocompatibility antigen, DQ alpha 1 chain protein (24-213AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA, IHC; Recommended dilution : IHC : 1 : 20-1 : 200
Background : Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molec µLes are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molec µLes, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molec µLes and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molec µLe that presents an antigen, three MHC class II molec µLes (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molec µLes until primary high affinity antigenic peptides are bound. The MHC II molec µLe bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molec µLes is reg µLated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal miroenvironment has been implicated in the reg µLation of antigen loading into MHC II molec µLes, increased acidification produces increased proteolysis and efficient peptide loading.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : HLA-DQA1
Research Areas : Immunology

Volume : 50 µg
Clone Number :
Aliases : beta1 domain MHC class II HLA DPB antibody; class II histocompatibility antigen; DP(W4) beta chain antibody; class II HLA beta chain antibody; DP beta 1 chain antibody; DP(W4) beta chain antibody; DPB1 antibody; DPB1_HUMAN antibody; HLA class II histocompatibility antigen antibody; HLA class II histocompatibility antigen; DP beta 1 chain antibody; HLA class II histocompatibility antigen; DP(W4) beta chain antibody; HLA DP14-beta chain antibody; HLA-DP antibody; HLA-DP histocompatibility type; beta-1 subunit antibody; HLA-DP1B antibody; HLA-DPB antibody; HLA-DPB1 antibody; major histocompatibility complex class II antigen beta chain antibody; major histocompatibility complex; class II; DP beta 1 antibody; MHC class II antigen beta chain antibody; MHC class II antigen DP beta 1 chain antibody; MHC class II antigen DPB1 antibody; MHC class II antigen DPbeta1 antibody; MHC class II HLA-DP-beta-1 antibody; MHC class II HLA-DRB1 antibody; MHC HLA DPB1 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P04440
Immunogen : Recombinant Human HLA class II histocompatibility antigen, DP beta 1 chain protein (30-225AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molec µLes are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molec µLes, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molec µLes and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molec µLe that presents an antigen, three MHC class II molec µLes (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molec µLes until primary high affinity antigenic peptides are bound. The MHC II molec µLe bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molec µLes is reg µLated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal miroenvironment has been implicated in the reg µLation of antigen loading into MHC II molec µLes, increased acidification produces increased proteolysis and efficient peptide loading.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : HLA-DPB1
Research Areas : Immunology

Volume : 50 µg
Clone Number :
Aliases : HLA-DPA1 antibody; HLA-DP1A antibody; HLASBHLA class II histocompatibility antigen antibody; DP alpha 1 chain antibody; DP(W3) antibody; DP(W4) antibody; HLA-SB alpha chain antibody; MHC class II DP3-alpha antibody; MHC class II DPA1 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P20036
Immunogen : Recombinant Human HLA class II histocompatibility antigen, DP alpha 1 chain protein (29-222AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molec µLes are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molec µLes, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molec µLes and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molec µLe that presents an antigen, three MHC class II molec µLes (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molec µLes until primary high affinity antigenic peptides are bound. The MHC II molec µLe bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molec µLes is reg µLated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal miroenvironment has been implicated in the reg µLation of antigen loading into MHC II molec µLes, increased acidification produces increased proteolysis and efficient peptide loading.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : HLA-DPA1
Research Areas : Immunology