Volume : 50 µg
Clone Number :
Aliases : Cbfa2t3 antibody; Ccore binding factor runt domain alpha subunit 2 translocated to 3 antibody; ETO2 antibody; hMTG16 antibody; hMTG16a antibody; hMTG16b antibody; MTG16 antibody; MTG16_HUMAN antibody; MTG8 related gene 2 antibody; MTG8 related protein MTG16a antibody; MTG8 related protein MTG16b antibody; MTG8-related protein 2 antibody; MTGR2 antibody; Myeloid translocation gene 8 and 16b antibody; Myeloid translocation gene on chromosome 16 protein antibody; Protein CBFA2T3 antibody; Zinc finger MYND domain-containing protein 4 antibody; ZMYND4 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : O75081
Immunogen : Recombinant Human Protein CBFA2T3 protein (39-159AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed : 12559562, PubMed : 15203199). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed : 23251453). Reduces the protein levels and stability of the transcriptinal reg µLator HIF1A; interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway (PubMed : 25974097). Contributes to inhibition of glycolysis and stim µLation of mitochondrial respiration by down-reg µLating the expression of glycolytic genes including PFKFB3, PFKFB4, PDK1 PFKP, LDHA and HK1 which are direct targets of HIF1A (PubMed : 23840896, PubMed : 25974097). Reg µLates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity). Plays a role in gran µLocyte differentiation (PubMed : 15231665).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : CBFA2T3
Research Areas : Epigenetics and Nuclear Signaling; Cancer