FITC

Volume : 50 µg
Clone Number :
Aliases : BOM antibody; Brother of mammalian grainyhead antibody; Deafness autosomal dominant 28 antibody; DFNA28 antibody; ECTDS antibody; FLJ11172 antibody; FLJ13782 antibody; Grainyhead like 2 (Drosophila) antibody; Grainyhead like 2 antibody; Grainyhead like protein 2 homolog antibody; Grainyhead like transcription factor 2 antibody; Grainyhead-like protein 2 homolog antibody; GRHL 2 antibody; GRHL2 antibody; GRHL2_HUMAN antibody; MGC149294 antibody; MGC149295 antibody; RGD1561191 antibody; TFCP2L3 antibody; Transcription factor CP2 like 3 antibody; Transcription factor CP2-like 3 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q6ISB3
Immunogen : Recombinant Human Grainyhead-like protein 2 homolog protein (1-265AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : Transcription factor playing an important role in primary neur µLation and in epithelial development (PubMed : 25152456). Binds directly to the consensus DNA sequence 5\\\'-AACCGGTT-3\\\' acting as an activator and repressor on distinct target genes. During embryogenesis, plays unique and cooperative roles with GRHL3 in establishing distinct zones of primary neur µLation. Essential for closure 3 (rostral end of the forebrain), functions cooperatively with GRHL3 in closure 2 (forebrain/midbrain boundary) and posterior neuropore closure. Reg µLates epithelial morphogenesis acting as a target gene-associated transcriptional activator of apical junctional complex components. Up-reg µLates of CLDN3 and CLDN4, as well as of RAB25, which increases the CLDN4 protein and its localization at tight junctions. Comprises an essential component of the transcriptional machinery that establishes appropriate expression levels of CLDN4 and CDH1 in different types of epithelia. Exhibits functional redundancy with GRHL3 in epidermal morphogenetic events and epidermal wound repair. In lung, forms a reg µLatory loop with NKX2-1 that coordinates lung epithelial cell morphogenesis and differentiation. In keratinocytes, plays a role in telomerase activation during cell µLar proliferation, reg µLates TERT expression by binding to TERT promoter region and inhibiting DNA methylation at the 5\\\'-CpG island, possibly by interfering with DNMT1 enzyme activity (PubMed : 19015635, PubMed : 20938050). In addition, impairs keratinocyte differentiation and epidermal function by inhibiting the expression of genes clustered at the epidermal differentiation complex (EDC) as well as GRHL1 and GRHL3 thro µgh epigenetic mechanisms (PubMed : 23254293).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : Antigen Affinity Purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : GRHL2
Research Areas : Epigenetics and Nuclear Signaling; Neuroscience

Volume : 50 µL
Clone Number :
Aliases : Grainyhead-like protein 1 homolog antibody; grhl1 antibody; GRHL1_HUMAN antibody; LBP32 antibody; Mammalian grainyhead antibody; MGR antibody; NH32 antibody; TFCP2L2 antibody; Transcription factor CP2-like 2 antibody; Transcription factor LBP-32 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q9NZI5
Immunogen : Recombinant Human Grainyhead-like protein 1 homologprotein (1-95AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : Transcription factor involved in epithelial development. Binds directly to the consensus DNA sequence 5\'-AACCGGTT-3\' (PubMed : 12175488, PubMed : 18288204). Important reg µLator of DSG1 in the context of hair anchorage and epidermal differentiation, participates in the maintenance of the skin barrier. There is no genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity during epithelia development (By similarity). Isoform 1 may function as an activator and isoform 2 as a repressor in tissues where both forms are expressed (PubMed : 12175488).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : GRHL1
Research Areas : Epigenetics and Nuclear Signaling

Volume : 50 µg
Clone Number :
Aliases : BMP antagonist 1 antibody; Cell proliferation inducing gene 2 protein antibody; Cell proliferation-inducing gene 2 protein antibody; CKTSF1B1 antibody; colorectal adenoma and carcinoma 1 antibody; Cysteine knot superfamily 1 antibody; Cysteine knot superfamily 1; BMP antagonist 1 antibody; Cysteine knot superfamily BMP antagonist 1 antibody; DAN domain family member 2 antibody; DAND2 antibody; Down reg µLated in Mos-transformed cells protein antibody; Down-reg µLated in Mos-transformed cells protein antibody; DRM antibody; grem1 antibody; GREM1_HUMAN antibody; Gremlin 1 homolog; cysteine knot superfamily antibody; Gremlin 1 like protein antibody; Gremlin 1; cysteine knot superfamily; homolog antibody; GREMLIN antibody; Gremlin-1 antibody; Gremlin1 antibody; IHG-2 antibody; IHG2 antibody; Increased in high glucose 2 antibody; Increased in high glucose protein 2 antibody; PIG2 antibody; Proliferation inducing gene 2 antibody; proliferation inducing gene 2 protein antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : O60565
Immunogen : Recombinant Human Gremlin-1 protein (18-184AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-reg µLates the BMP4 signaling in a dose-dependent manner (By similarity). Antagonist of BMP2; inhibits BMP2-mediated differentiation of osteoblasts (in vitro) (PubMed : 27036124). Acts as inhibitor of monocyte chemotaxis. Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed (By similarity).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : GREM1
Research Areas : Signal transduction; Stem cells

Volume : 50 µg
Clone Number :
Aliases : Abundant SRC homology antibody; Adapter protein GRB2 antibody; ASH antibody; Ash protein antibody; EGFRBP GRB2 antibody; Epidermal growth factor receptor binding protein antibody; Epidermal growth factor receptor binding protein GRB2 antibody; GRB 2 antibody; GRB2 adapter protein antibody; Grb2 antibody; GRB2_HUMAN antibody; Grb3 3 antibody; Growth factor receptor bound protein 2 antibody; Growth factor receptor bound protein 3 antibody; Growth factor receptor-bound protein 2 antibody; HT027 antibody; MST084 antibody; MSTP084 antibody; NCKAP2 antibody; OTTHUMP00000166096 antibody; OTTHUMP00000166097 antibody; OTTHUMP00000166098 antibody; Protein ash antibody; SEM5 antibody; SH2/SH3 adapter GRB2 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P62993
Immunogen : Recombinant Human Growth factor receptor-bound protein 2 protein (11-200AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : GRB2
Research Areas : Cancer; Signal transduction

Volume : 50 µg
Clone Number :
Aliases : GRB14Growth factor receptor-bound protein 14 antibody; GRB14 adapter protein antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q14449
Immunogen : Recombinant Human Growth factor receptor-bound protein 14 protein (294-397AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : Adapter protein which mod µLates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated ins µLin receptor (INSR). Potent inhibitor of ins µLin-stim µLated MAPK3 phosphorylation. Plays a critical role reg µLating PDPK1 membrane translocation in response to ins µLin stim µLation and serves as an adapter protein to recruit PDPK1 to activated ins µLin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the ins µLin signal.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : GRB14
Research Areas : Signal transduction

Volume : 50 µg
Clone Number :
Aliases : grb 10 antibody; GRB IR antibody; grb-10 antibody; GRB10 adapter protein antibody; GRB10 adaptor protein antibody; GRB10 antibody; GRB10_HUMAN antibody; GRBIR antibody; Growth factor receptor bound protein 10 antibody; Growth factor receptor-bound protein 10 antibody; Ins µLin receptor binding protein antibody; Ins µLin receptor binding protein GRB IR antibody; Ins µLin receptor-binding protein Grb-IR antibody; IRBP antibody; KIAA0207 antibody; Maternally expressed gene 1 antibody; MEG1 antibody; RSS antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q13322
Immunogen : Recombinant Human Growth factor receptor-bound protein 10 protein (15-180AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : Adapter protein which mod µLates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the ins µLin (INSR) and ins µLin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms : interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to ins µLin stim µLation. Blocks association between INSR and IRS1 and IRS2 and prevents ins µLin-stim µLated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating ins µLin-stim µLated ubiquitination of INSR, leading to proteasomal degradation. Negatively reg µLates Wnt signaling by interacting with LRP6 intracell µLar portion and interfering with the binding of AXIN1 to LRP6. Positive reg µLator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : GRB10
Research Areas : Signal transduction

Volume : 50 µL
Clone Number :
Aliases : GRB2-related adapter protein 2 (Adapter protein GRID) (GRB-2-like protein) (GRB2L) (GRBLG) (GRBX) (Grf40 adapter protein) (Grf-40) (Growth factor receptor-binding protein) (Hematopoietic cell-associated adapter protein GrpL) (P38) (Protein GADS) (SH3-SH2-SH3 adapter Mona), GRAP2, GADS GRB2L GRID
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : O75791
Immunogen : Recombinant Human GRB2-related adapter protein 2 protein (149-251aa)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : Interacts with SLP-76 to reg µLate NF-AT activation. Binds to tyrosine-phosphorylated shc.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : GRAP2
Research Areas : Cancer; Signal transduction

Volume : 50 µL
Clone Number :
Aliases : Grap antibody; GRAP_HUMAN antibody; GRB2 related adaptor protein antibody; GRB2-related adapter protein antibody; Growth factor receptor bound protein 2 related adaptor protein antibody; MGC64880 antibody; OTTHUMP00000065766 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q13588
Immunogen : Recombinant Human GRB2-related adapter protein (1-217AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : Antigen Affinity Purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : GRAP
Research Areas : Signal transduction

Volume : 50 µg
Clone Number :
Aliases : Death-inducing protein antibody; GRAM domain-containing protein 4 antibody; GRAM4_HUMAN antibody; GRAMD4 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q6IC98
Immunogen : Recombinant Human GRAM domain-containing protein 4 protein (23-161AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : Plays a role as a mediator of E2F1-induced apoptosis in the absence of p53/TP53.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : GRAMD4
Research Areas : Others

Volume : 50 µg
Clone Number :
Aliases : GRAMD1B antibody; KIAA1201 antibody; UNQ3032/PRO9834Protein Aster-B antibody; GRAM domain-containing protein 1B antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q3KR37
Immunogen : Recombinant Human GRAM domain-containing protein 1B protein (235-504AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background :
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : GRAMD1B
Research Areas : Cell biology

Volume : 50 µg
Clone Number :
Aliases : GRA1Dense gran µLe protein 1 antibody; Protein GRA 1 antibody; Major antigen p24 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Toxoplasma gondii
UniProt ID : P13403
Immunogen : Recombinant Toxoplasma gondii Dense gran µLe protein 1 protein (26-187AA)
Raised in : Rabbit
Species Reactivity : Toxoplasma gondii
Tested Applications :
Background :
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : GRA1
Research Areas : Others